We determined in vivo efficacy and target PK/PD exposures of antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in the murine pneumonia model. The mean plasma free drug area under the concentration-time curve/MIC (fAUC/MIC) targets associated with stasis and 1-log₁₀ and 2-log₁₀ kill effects were 8.93, 19.2, and 48.1, respectively, for S. pneumoniae, whereas they were 30.5, 55.4, and 115.8, respectively, for S. aureus. The fAUC/MIC targets in murine lung epithelial lining fluids (ELF) for the same endpoints were nearly 2-fold higher than those in plasma.

中文翻译：

---

抗中性粒细胞减少性鼠肺炎模型中安非沙星抗肺炎链球菌和金黄色葡萄球菌的体内药效学目标评估。

我们在小鼠肺炎模型中确定了抗氧肺炎链球菌和金黄色葡萄球菌的安妥沙星的体内功效和靶向PK / PD暴露。肺炎链球菌与停滞和1-log ₁₀和2-log ₁₀杀伤作用相关的浓度-时间曲线/ MIC（f AUC / MIC）指标下的平均无血浆药物面积分别为8.93、19.2和48.1 。，而金黄色葡萄球菌分别为30.5、55.4和115.8 。相同终点的鼠肺上皮衬里液（ELF）中的f AUC / MIC目标比血浆中的目标高近2倍。