Storage lipids, triacylglycerols (TAG), and steryl esters (SE), are predominant constituents of lipid droplets (LD) in fungi. In several yeast species, metabolism of TAG and SE is linked to various cellular processes, including cell division, sporulation, apoptosis, response to stress, and lipotoxicity. In addition, TAG are an important source for the generation of value‐added lipids for industrial and biomedical applications. The fission yeast Schizosaccharomyces pombe is a widely used unicellular eukaryotic model organism. It is a powerful tractable system used to study various aspects of eukaryotic cellular and molecular biology. However, the knowledge of S. pombe neutral lipids metabolism is quite limited. In this review, we summarize and discuss the current knowledge of the homeostasis of storage lipids and of the role of LD in the fission yeast S. pombe with the aim to stimulate research of lipid metabolism and its connection with other essential cellular processes. We also discuss the advantages and disadvantages of fission yeast in lipid biotechnology and recent achievements in the use of S. pombe in the biotechnological production of valuable lipid compounds.

中文翻译：

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储存脂质的代谢和脂质液滴在酵母裂殖酵母中的作用。

储存脂质、三酰基甘油 (TAG) 和甾醇酯 (SE) 是真菌中脂滴 (LD) 的主要成分。在几个酵母物种中，TAG 和 SE 的代谢与各种细胞过程有关，包括细胞分裂、孢子形成、细胞凋亡、应激反应和脂毒性。此外，TAG 是产生用于工业和生物医学应用的增值脂质的重要来源。裂殖酵母粟酒裂殖酵母是一种广泛使用的单细胞真核模型生物。它是一个强大的易处理系统，用于研究真核细胞和分子生物学的各个方面。然而，S. pombe的知识中性脂质代谢相当有限。在这篇综述中，我们总结和讨论了目前关于储存脂质体内平衡和 LD 在裂变酵母S. pombe中的作用的知识，旨在刺激脂质代谢及其与其他基本细胞过程的联系的研究。我们还讨论了裂殖酵母在脂质生物技术中的优缺点，以及在使用S. pombe生物技术生产有价值的脂质化合物方面的最新成果。