Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation: Focus on the medial forebrain bundle,European Journal of Neuroscience

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Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation: Focus on the medial forebrain bundle
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-09-15 , DOI: 10.1111/ejn.14975
Máté D. Döbrössy _{1,

2} , Chockalingam Ramanathan ₁ , Danesh Ashouri Vajari ₃ , Yixin Tong ₁ , Thomas Schlaepfer _{4,

5} , Volker A. Coenen _{1,

2,

4,

6}

Affiliation

Deep brain stimulation (DBS) in psychiatric illnesses has been clinically tested over the past 20 years. The clinical application of DBS to the superolateral branch of the medial forebrain bundle in treatment‐resistant depressed patients—one of several targets under investigation—has shown to be promising in a number of uncontrolled open label trials. However, there are remain numerous questions that need to be investigated to understand and optimize the clinical use of DBS in depression, including, for example, the relationship between the symptoms, the biological substrates/projections and the stimulation itself. In the context of precision and customized medicine, the current paper focuses on clinical and experimental research of medial forebrain bundle DBS in depression or in animal models of depression, demonstrating how clinical and scientific progress can work in tandem to test the therapeutic value and investigate the mechanisms of this experimental treatment. As one of the hypotheses is that depression engenders changes in the reward and motivational networks, the review looks at how stimulation of the medial forebrain bundle impacts the dopaminergic system.

中文翻译：

精神疾病中的神经调节：奖励和动机网络的实验和临床证据深度脑部刺激：专注于内侧前脑束

在过去的20年中，对精神疾病中的深部脑刺激（DBS）进行了临床测试。在许多不受控制的开放标签试验中，DBS在耐治疗性抑郁症患者（正在研究的几个靶标之一）中在前脑内侧束上外侧分支上的临床应用已显示出希望。但是，仍然有许多问题需要调查，以了解和优化DBS在抑郁症中的临床应用，例如，包括症状，生物学底物/突起与刺激本身之间的关系。在精准医学和定制医学的背景下，本论文着重研究抑郁症或抑郁症动物模型中前脑内侧束DBS的临床和实验研究，演示临床和科学进步如何协同工作以测试治疗价值并研究这种实验性治疗的机制。由于假设之一是抑郁症会导致奖励和动机网络的变化，因此该综述着眼于内侧前脑束的刺激如何影响多巴胺能系统。

更新日期：2020-09-15

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