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Original method of imprinting pores in scaffolds for tissue engineering
Polymers for Advanced Technologies ( IF 3.4 ) Pub Date : 2020-09-15 , DOI: 10.1002/pat.5091
Agnieszka Gadomska‐Gajadhur 1 , Aleksandra Kruk 1 , Paweł Ruśkowski 1 , Paweł Sajkiewicz 2 , Judyta Dulnik 2 , Andrzej Chwojnowski 3
Affiliation  

Results of the preparation of biodegradable porous scaffolds using an original modification of a wet phase inversion method were presented. Influence of gelatin non‐woven as a non‐classic pore precursor and polyvinylpyrrolidone, Pluronic as classic pore precursors on the structure of obtained scaffolds was analyzed. It was shown that the addition of gelatin non‐wovens enables the preparation of scaffolds, which allow for the growth of cells (size, distribution, and shape of pores). Mechanical properties of the obtained cell scaffolds were determined. The influence of pore precursors on mass absorption of scaffolds against isopropanol and plasma was investigated. Interaction of scaffolds with a T‐lymphocyte line (Jurkat) and with fibroblasts (L929) was investigated. Obtained scaffolds are not cytotoxic and can be used as implants, for example, the regeneration of cartilage tissue.

中文翻译:

印迹组织工程支架中孔的原始方法

提出了使用湿相转化方法的原始改进方法制备可生物降解的多孔支架的结果。分析了明胶无纺布作为非经典孔前体和聚乙烯吡咯烷酮,普流罗尼克作为经典孔前体对所得支架结构的影响。结果表明,添加明胶无纺布可以制备支架,从而使细胞生长(孔的大小,分布和形状)。测定获得的细胞支架的机械性能。研究了孔前体对支架对异丙醇和血浆质量吸收的影响。研究了支架与T淋巴细胞系(Jurkat)和成纤维细胞(L929)的相互作用。获得的支架没有细胞毒性,可以用作植入物,例如,
更新日期:2020-09-15
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