Tunable Synthesis of Mesoporous Prussian Blue@Calcium Phosphate Nanoparticles for Synergic Chemo‐Photothermal Cancer Therapy,ChemistrySelect

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Tunable Synthesis of Mesoporous Prussian Blue@Calcium Phosphate Nanoparticles for Synergic Chemo‐Photothermal Cancer Therapy
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-09-15 , DOI: 10.1002/slct.202001234
Baohui Yu ₁ , Chungang Wang ₂

Affiliation

A facile and mild strategy to prepare the mesoporous prussian blue@calcium phosphate core‐shell nanoparticles (M‐PB@CaP core‐shell NPs) composed with a MCaP shell and a MPB core is reported. The obtained NPs exhibited strong absorption in the near infrared (NIR) region and possessed an excellent photothermal efficiency of 26 % resulting from the PB core. The mesoporous structure of PB, CaP and the appearance of PAA in the M‐PB@CaP core‐shell NPs are greatly favorable for the ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs) of the NPs. When the DOX‐loaded M‐PB@CaP core‐shell NPs were exposed to NIR irradiation, a burst‐like drug release occurs on account of the heat produced by the M‐PB@CaP core‐shell NPs. These results indicate that the obtained NPs could employ as pH/NIR dual‐responsive drug delivery systems for synergistic chemo‐photothermal therapy of cancer cells.

中文翻译：

可调谐合成的介孔普鲁士蓝@磷酸钙纳米粒子的协同化学光热癌治疗。

报道了一种简便而温和的策略来制备由MCaP壳和MPB核组成的介孔普鲁士蓝@磷酸钙核壳纳米颗粒（M-PB @ CaP核壳NP）。所获得的NP在PB核心中表现出在近红外（NIR）区域的强吸收性，并具有26％的出色光热效率。PB，CaP的介孔结构和M‐PB @ CaP核壳NP中PAA的出现极大地有利于NP的超高阿霉素（DOX）负载能力（1 mg DOX / mg NP）。当将装载DOX的M-PB @ CaP核壳NP暴露在NIR辐射下时，由于M-PB @ CaP核壳NP产生的热量，会发生突释状药物释放。

更新日期：2020-09-15

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