Synthesis and Metabolic Fate of 4‐Methylthiouridine in Bacterial tRNA,ChemBioChem

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Synthesis and Metabolic Fate of 4‐Methylthiouridine in Bacterial tRNA
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-15 , DOI: 10.1002/cbic.202000637
Christoph Borek ₁ , Valentin F. Reichle ₁ , Stefanie Kellner ₁

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The cover feature picture shows a tRNA that is being transported through the bacterial “RNA maintenance factory” after being damaged through direct methylation. Here, we report how E. coli classifies RNA damage into three major categories. The first class of damage, such as 7‐methylguanosine is being ignored by the bacterium. The second class, for example, 2‐methylthiocytidine, is repaired through enzymatic demethylation. In the front, our newly discovered RNA damage, 4‐methylthiouridine, is shown; this is lost from tRNA through an as yet unknown mechanism. More information can be found in the communication by S. Kellner et al.

中文翻译：

细菌tRNA中4-甲基硫尿苷的合成及代谢命运

封面特征图片显示了通过直接甲基化作用被破坏后，正在通过细菌“ RNA维持工厂”运输的tRNA。在这里，我们报告大肠杆菌如何将RNA损伤分为三大类。细菌忽略了第一类伤害，例如7-甲基鸟苷。第二类，例如2-甲基硫代胞苷，通过酶促脱甲基作用修复。在前面，显示了我们新发现的RNA损伤4-甲基硫尿苷；这通过未知的机制从tRNA中消失了。可以在S. Kellner等人的来文中找到更多信息。

更新日期：2020-10-02

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