In situ product recovery techniques aiming to obtain biotechnological products: A glance to current knowledge,Biotechnology and Applied Biochemistry

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In situ product recovery techniques aiming to obtain biotechnological products: A glance to current knowledge
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-09-15 , DOI: 10.1002/bab.2024
Ariane G Santos ₁ , Tiago L de Albuquerque ₁ , Bernardo D Ribeiro ₁ , Maria Alice Z Coelho ₁

Affiliation

Biotechnology and bioengineering techniques have been widely used in the production of biofuels, chemicals, pharmaceuticals, and food additives, being considered a “green” form of production because they use renewable and nonpolluting energy sources. On the other hand, in the traditional processes of production, the target product obtained by biotechnological routes must undergo several stages of purification, which makes these processes more expensive. In the past few years, some works have focused on processes that integrate fermentation to the recovery and purification steps necessary to obtain the final product required. This type of process is called in situ product recovery or extractive fermentation. However, there are some differences in the concepts of the techniques used in these bioprocesses. In this way, this review sought to compile relevant content on considerations and procedures that are being used in this field, such as evaporation, liquid–liquid extraction, permeation, and adsorption techniques. Also, the objective of this review was to approach the different configurations in the recent literature of the processes employed and the main bioproducts obtained, which can be used in the food, pharmaceutical, chemical, and/or fuel additives industry. We intended to elucidate concepts of these techniques, considered very recent, but which emerge as a promising alternative for the integration of bioprocesses.

中文翻译：

旨在获得生物技术产品的原位产品回收技术：当前知识概览

生物技术和生物工程技术已广泛用于生物燃料、化学品、药品和食品添加剂的生产，被认为是一种“绿色”生产形式，因为它们使用可再生和无污染的能源。另一方面，在传统的生产过程中，通过生物技术途径获得的目标产品必须经过几个阶段的纯化，这使得这些过程更加昂贵。在过去几年中，一些工作集中在将发酵与获得所需最终产品所需的回收和纯化步骤相结合的过程。这种类型的过程称为原位产品回收或提取发酵。但是，这些生物过程中使用的技术概念存在一些差异。这样，本综述试图汇编有关该领域正在使用的考虑因素和程序的相关内容，例如蒸发、液-液萃取、渗透和吸附技术。此外，本综述的目的是探讨近期文献中所采用的工艺和获得的主要生物产品的不同配置，这些产品可用于食品、制药、化学和/或燃料添加剂行业。我们打算阐明这些技术的概念，这些技术被认为是最近的，但它们作为生物过程集成的有前途的替代方案而出现。本综述的目的是探讨近期文献中所采用的工艺和获得的主要生物产品的不同配置，这些配置可用于食品、制药、化学和/或燃料添加剂行业。我们打算阐明这些技术的概念，这些技术被认为是最近的，但它们作为生物过程集成的有前途的替代方案而出现。本综述的目的是探讨近期文献中所采用的工艺和获得的主要生物产品的不同配置，这些配置可用于食品、制药、化学和/或燃料添加剂行业。我们打算阐明这些技术的概念，这些技术被认为是最近的，但它们作为生物过程集成的有前途的替代方案而出现。

更新日期：2020-09-15

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