Liver cirrhosis accompanied with hepatic encephalopathy commonly causes cognitive impairment in patients. To model this disease, two independent patient specific induced pluripotent stem cell-line (iPSC) clones, NCCSi011-A and NCCSi011-B were generated by reprogramming the CD4⁺ T cells of an Indian male patient suffering from this chronic condition. Both clones expressed the stemness markers, formed embryoid bodies (EBs) with potential for spontaneous differentiation in to all the three lineages, exhibited normal karyotype (46, XY) and demonstrated alkaline phosphatase activity. These generated iPSC lines have potential for use in understanding biology of the disease and evaluation of drugs.

肝硬化并发肝性脑病通常会引起患者认知障碍。为了对该疾病进行建模，通过对患有这种慢性病的印度男性患者的CD4 ⁺ T细胞进行重新编程，生成了两个独立的患者特异性诱导多能干细胞系（iPSC）克隆NCCSi011-A和NCCSi011-B 。这两个克隆都表达了干性标记，形成了可能自发分化成所有三个谱系的胚状体（EB），表现出正常的核型（46，XY），并表现出碱性磷酸酶活性。这些产生的iPSC品系具有潜在用途，可用于了解疾病的生物学和评估药物。