Abstract Microparticles containing the photosensitive spinosad (SP) were obtained using a combination of chitosan (CH) and sodium lignosulfonate (SL) as encapsulating materials to develop a photoprotective system for intake administration. The microparticles were obtained by a spray drying technique and were characterized in terms of morphology (scanning electron microscopy - SEM) and particle size. In vitro release studies showed an initial burst effect that fits very well with the zero order kinetic model and then a slow release of the bioinsecticide, which fits best with the first order model. The results of this work demonstrate that the bioinsecticide carrier system developed with natural polymeric materials presents high stability to photodegradation and adequate insecticide release for use as a strategy to reduce negative impacts on the environment in agronomic practices.

中文翻译：

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喷雾干燥获得的多杀菌素生物聚合物微粒的光保护和释放研究

摘要 使用壳聚糖 (CH) 和木质素磺酸钠 (SL) 的组合作为封装材料，开发了一种用于摄入给药的光保护系统，获得了含有光敏多杀菌素 (SP) 的微粒。微粒通过喷雾干燥技术获得，并在形态学（扫描电子显微镜 - SEM）和粒度方面进行表征。体外释放研究表明，初始爆发效应与零级动力学模型非常吻合，然后是生物杀虫剂的缓慢释放，最适合一级模型。