Abstract Embelin is a natural agent with antimicrobial, antifungal and analgesic activities. This work presents a mechanistic model for the release of embelin from a polycaprolactone matrix. Based on the results of embelin release experiments and Raman microscopy measurements, the model assumes a dual dispersion of the embelin: agglomerated and dispersed. Embelin release mechanism combines the effects of the liquid migration into the matrix, the drug diffusion, and the drug dissolution within the wetted matrix. The model is formulated in terms of four partial differential equations that account for the mass balances of dispersed, agglomerated, and dissolved embelin, and aqueous solution. Model predictions show that the release mechanism involves three stages: a burst stage, in which dispersed embelin is rapidly released; a transition stage, in which dispersed and agglomerated embelin are simultaneously released; and, once the dispersed embelin depletion, a stable release stage until the agglomerated embelin exhausts.

中文翻译：

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从聚己内酯基质中释放 embelin 的机制模型的开发和验证

摘要 Embelin 是一种具有抗菌、抗真菌和镇痛活性的天然药物。这项工作提出了一种从聚己内酯基质中释放 embelin 的机制模型。根据 embelin 释放实验和拉曼显微镜测量的结果，该模型假设 embelin 的双重分散：团聚和分散。Embelin 释放机制结合了液体迁移到基质中、药物扩散和药物在润湿基质内溶解的影响。该模型是根据四个偏微分方程制定的，这些方程解释了分散、凝聚和溶解的 embelin 和水溶液的质量平衡。模型预测表明，释放机制包括三个阶段：爆发阶段，其中分散的 embelin 被迅速释放；过渡阶段，其中分散和凝聚的embelin同时释放；并且，一旦分散的 embelin 耗尽，一个稳定的释放阶段，直到聚集的 embelin 耗尽。