Abstract Characterizing polarization of skin pathologies is still an interested issue for the dermatology community. In a previous study, the present group proposed a Stokes–Muellermatrix polarimetry for differentiating between squamous cell carcinoma tissue and normal healthy tissue in mice. The present study extends our method to the detection of squamous cell carcinoma, basal cell carcinoma and melanoma skin cancer in humans. Using the proposed method, the orientation angle of linear birefringence ( α ), phase retardance ( β ), optical rotation angle of circular birefringence ( γ ), orientation angle of linear dichroism ( θ d ), linear dichroism (D), circular dichroism (R), degrees of linear depolarization ( e 1 and e 2 ), degree of circular depolarization ( e 3 ), and depolarization index ( Δ ) are extracted for 72 slices of 12 squamous cell carcinoma samples, 72 slices of 12 basal cell carcinoma samples, 18 slices of 3 melanoma skin cancer samples, and 36 slices of 6 healthy samples. The experimental results show that the cancerous tissue exhibits lower phase retardance ( β ) and linear dichroism (D) than healthy skin tissue. Overall, the proposed method provides a useful insight into the characterization optical properties of human skin cancer by Stokes–Mueller matrix polarimetry.

中文翻译：

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使用 Stokes-Mueller 旋光技术表征健康和癌变的人体皮肤组织

摘要 表征皮肤病理的极化仍然是皮肤病学界感兴趣的问题。在之前的一项研究中，本小组提出了 Stokes-Muellermatrix 极化法，用于区分小鼠鳞状细胞癌组织和正常健康组织。本研究将我们的方法扩展到检测人类鳞状细胞癌、基底细胞癌和黑色素瘤皮肤癌。使用所提出的方法，线性双折射的取向角（ α ）、相位延迟（ β ）、圆双折射的旋光角（ γ ）、线性二向色性的取向角（ θ d ）、线性二向色性（D）、圆二向色性（ R), 线性去极化度 (e 1 和 e 2 ), 圆形去极化度 (e 3 ), 对12个鳞状细胞癌样本的72个切片、12个基底细胞癌样本的72个切片、3个黑色素瘤皮肤癌样本的18个切片和6个健康样本的36个切片提取了去极化指数(Δ)。实验结果表明，癌变组织表现出比健康皮肤组织更低的相位延迟（β）和线性二色性（D）。总体而言，所提出的方法为通过斯托克斯-穆勒矩阵偏振法表征人类皮肤癌的光学特性提供了有用的见解。