Abstract Insufficient penetration of therapeutic agents into tumor tissues results in an inadequate distribution of the agents and lower intracellular concentrations, leading to drug resistance and treatment failure. Specific delivery of therapeutic agents to solid tumors followed by high penetration and durable retention would hold great promise to improve current chemotherapy. Particularly, a smart Janus-like surface-coated mitochondria system was well designed and developed, which could mimic the natural bacterial to use the glucose as the fuel to swim directional to the tumors and spontaneously penetrate the depth of tumor tissues and retained for quite a long time. Moreover, the delivered healthy mitochondria could help the apoptotic signal activation and transmission to enhance the therapeutic performance of commercial anti-cancer drugs, epirubicin. Different from other strategies, the modified mitochondria acted like natural biosystems to actively accumulate in the tumors following the glucose gradient in the microenvironment. We believe this unique organelle-material complex would serve as highly promising candidates to combat multidrug resistance in future chemotherapy.

中文翻译：

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基于趋化性的表面工程线粒体的自我积累以改善癌症治疗

摘要 治疗药物对肿瘤组织的渗透不足导致药物分布不充分和细胞内浓度降低，导致耐药性和治疗失败。将治疗剂特异性递送至实体瘤，然后进行高渗透性和持久保留，将有望改善当前的化疗。特别是设计开发了一个智能的类Janus表面包被的线粒体系统，它可以模仿天然细菌以葡萄糖为燃料，向肿瘤方向游动，自发穿透肿瘤组织深处，并保留相当长的时间。很久。此外，输送的健康线粒体可以帮助细胞凋亡信号的激活和传递，从而提高商业抗癌药物的治疗性能，表柔比星。与其他策略不同的是，经过修饰的线粒体像天然生物系统一样，随着微环境中的葡萄糖梯度在肿瘤中积极积累。我们相信这种独特的细胞器-材料复合物将成为在未来化疗中对抗多药耐药性的非常有希望的候选者。