Abstract A composite scaffold comprising a silk fibroin (SF) sponge on functionally graded titanium (FG-Ti) was developed. The FG-Ti showed a radial graded structure similar to native long bone and better mechanical properties than those of homogeneous porous Ti with the same porosity. The microstructure of the composite scaffold was observed using scanning electron microscopy. The SF sponge filled in FG-Ti exhibited interconnected pore architecture, which could provide a suitable environment for cell attachment. The in vitro biocompatibility of the composite scaffolds was investigated using rat osteoblastic cells. Compared to FG-Ti, composite scaffolds exhibited an improved osteoblast adhesion and proliferation. These results suggest that the composite scaffold is a good candidate as a bone repair scaffold.

中文翻译：

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用于骨修复的功能梯度多孔钛/丝素蛋白复合支架的开发

摘要 开发了一种在功能梯度钛 (FG-Ti) 上包含丝素蛋白 (SF) 海绵的复合支架。FG-Ti 显示出类似于天然长骨的径向渐变结构，并且比具有相同孔隙率的均质多孔钛具有更好的机械性能。使用扫描电子显微镜观察复合支架的微观结构。填充在 FG-Ti 中的 SF 海绵表现出相互连接的孔结构，可以为细胞附着提供合适的环境。使用大鼠成骨细胞研究复合支架的体外生物相容性。与 FG-Ti 相比，复合支架表现出改善的成骨细胞粘附和增殖。这些结果表明复合支架是作为骨修复支架的良好候选者。