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Development of hydrazide based fluorescence probe for detection of Al3+ ions and application in live cell image
Journal of Photochemistry and Photobiology A: Chemistry ( IF 4.1 ) Pub Date : 2020-09-15 , DOI: 10.1016/j.jphotochem.2020.112921
Anu D. , Naveen P. , Rajamanikandan R. , V. Kaveri M.

Development of highly specific and susceptible sensors for aluminium (Al3+ ions) determination in water medium is still a remarkable task. Herein, a fluorescence probe (SCH) is derived from the condensation of salicyaldehyde and carbohydrazide in 2:1 M ratio and promising chemical sensing of Al3+ ions is investigated. Examinations of the emission features of SCH in CH3OH:H2O (1:2, v/v) solution showed excellent turn on behaviour of Al3+ ions, which is due to 1:1 complex formation between SCH and the Al3+ ions at ambient conditions. The lowest limit of detection was estimated by emission titration experiments and found to be 32 nM which is much more 1000-fold lower than that WHO suggested maximum tolerable concentration. The present probe SCH was highly specific for the detection of Al3+ ions over other potential interfering metal cations. Based on the reversible emission behaviour, an INHIBIT logic gate was assembled with EDTA and Al3+ ions as two inputs. In addition, prospective application of SCH as cellular imaging sensor of Al3+ ions in MCF-7 cells was monitored using optical fluorescence microscopic images and real water samples.



中文翻译:

基于酰肼的Al 3+离子荧光探针的开发及其在活细胞图像中的应用

开发用于水介质中铝(Al 3+离子)测定的高特异性和易感传感器仍然是一项艰巨的任务。本文中,水杨醛和碳酰肼以2:1 M的比例缩合得到了荧光探针(SCH),并研究了有希望的化学传感Al 3+离子。对SCH在CH 3 OH:H 2 O(1:2,v / v)溶液中的发射特征的研究表明,Al 3+离子具有出色的开启行为,这是由于SCHAl之间形成了1:1的络合物3+离子在环境条件下。最低检测限是通过排放滴定实验估算的,发现为32 nM,比WHO所建议的最大可耐受浓度低1000倍。本探针SCH对检测其他潜在干扰金属阳离子上的Al 3+离子具有高度特异性。基于可逆的发射行为,组装了一个INHIBIT逻辑门,其中EDTA和Al 3+离子作为两个输入。另外,使用光学荧光显微图像和真实水样监测了SCH作为MCF-7细胞中Al 3+离子的细胞成像传感器的前瞻性应用。

更新日期:2020-09-21
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