Development of highly specific and susceptible sensors for aluminium (Al³⁺ ions) determination in water medium is still a remarkable task. Herein, a fluorescence probe (SCH) is derived from the condensation of salicyaldehyde and carbohydrazide in 2:1 M ratio and promising chemical sensing of Al³⁺ ions is investigated. Examinations of the emission features of SCH in CH₃OH:H₂O (1:2, v/v) solution showed excellent turn on behaviour of Al³⁺ ions, which is due to 1:1 complex formation between SCH and the Al³⁺ ions at ambient conditions. The lowest limit of detection was estimated by emission titration experiments and found to be 32 nM which is much more 1000-fold lower than that WHO suggested maximum tolerable concentration. The present probe SCH was highly specific for the detection of Al³⁺ ions over other potential interfering metal cations. Based on the reversible emission behaviour, an INHIBIT logic gate was assembled with EDTA and Al³⁺ ions as two inputs. In addition, prospective application of SCH as cellular imaging sensor of Al³⁺ ions in MCF-7 cells was monitored using optical fluorescence microscopic images and real water samples.

开发用于水介质中铝（Al ³⁺离子）测定的高特异性和易感传感器仍然是一项艰巨的任务。本文中，水杨醛和碳酰肼以2：1 M的比例缩合得到了荧光探针（SCH），并研究了有希望的化学传感Al ³⁺离子。对SCH在CH ₃ OH：H ₂ O（1：2，v / v）溶液中的发射特征的研究表明，Al ³⁺离子具有出色的开启行为，这是由于SCH和Al之间形成了1：1的络合物³⁺离子在环境条件下。最低检测限是通过排放滴定实验估算的，发现为32 nM，比WHO所建议的最大可耐受浓度低1000倍。本探针SCH对检测其他潜在干扰金属阳离子上的Al ³⁺离子具有高度特异性。基于可逆的发射行为，组装了一个INHIBIT逻辑门，其中EDTA和Al ³⁺离子作为两个输入。另外，使用光学荧光显微图像和真实水样监测了SCH作为MCF-7细胞中Al ³⁺离子的细胞成像传感器的前瞻性应用。