Background

The role of vitamin D in the susceptibility and severity of various viral diseases has been well documented. Recently, some reports highlighted the possible importance of vitamin D in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although India receives adequate sunlight throughout the year, the majority of Indians are deficient in vitamin D levels. In the present study, we hypothesized that vitamin D deficiency would be associated with the SARS-CoV-2 infection rate and mortality in the Indian population.

Materials and Methods

SARS-CoV-2 infection and mortality data were obtained from the Government of India's official website (accessed on 16^th August 2020). Various literature databases like PubMed and Google Scholar were searched to find the mean of 25-hydroxyvitamin D [25(OH)D] levels in different states and union territories of India, Pearson correlation was carried out to investigate the possible link between mean 25(OH)D levels and SARS-CoV-2 infection and mortality per million of the population.

Results

An inverse correlation was observed between the mean level of 25(OH)D and SARS-CoV-2 infection rate (r= -0.43, p= 0.02) and mortality rate (r= -0.42, p= 0.02).

Conclusions

The present observational study revealed an association of vitamin D with SARS-CoV-2 infection and related mortality. Further studies are required to validate our observations.

中文翻译：

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一项观察性研究表明，维生素D水平较低与印度人SARS-CoV-2感染和死亡率相关

背景

维生素D在各种病毒性疾病的易感性和严重性中的作用已得到充分证明。最近，一些报道强调了维生素D在严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）中的重要性。尽管印度全年都有充足的阳光，但大多数印度人维生素D水平不足。在本研究中，我们假设维生素D缺乏将与印度人口中的SARS-CoV-2感染率和死亡率相关。

材料和方法

SARS-CoV-2感染和死亡率数据来自印度政府的官方网站（于2020年8月16^日访问）。搜索了各种文献数据库，如PubMed和Google Scholar，以查找印度不同州和工会地区25-羟基维生素D [25（OH）D]水平的平均值，进行了Pearson相关性研究，以探讨平均值25（ OH）D水平以及SARS-CoV-2感染和每百万人口的死亡率。

结果

观察到25（OH）D的平均水平与SARS-CoV-2感染率（r = -0.43，p = 0.02）和死亡率（r = -0.42，p = 0.02）之间呈负相关。

结论

本观察性研究表明维生素D与SARS-CoV-2感染和相关死亡率有关。需要进一步研究以验证我们的观察结果。