当前位置: X-MOL 学术Int. Immunopharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: an observational study
International Immunopharmacology ( IF 4.8 ) Pub Date : 2020-09-14 , DOI: 10.1016/j.intimp.2020.107001
Sunali Padhi , Subham Suvankar , Venketesh K. Panda , Abhijit Pati , Aditya K. Panda

Background

The role of vitamin D in the susceptibility and severity of various viral diseases has been well documented. Recently, some reports highlighted the possible importance of vitamin D in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although India receives adequate sunlight throughout the year, the majority of Indians are deficient in vitamin D levels. In the present study, we hypothesized that vitamin D deficiency would be associated with the SARS-CoV-2 infection rate and mortality in the Indian population.

Materials and Methods

SARS-CoV-2 infection and mortality data were obtained from the Government of India's official website (accessed on 16th August 2020). Various literature databases like PubMed and Google Scholar were searched to find the mean of 25-hydroxyvitamin D [25(OH)D] levels in different states and union territories of India, Pearson correlation was carried out to investigate the possible link between mean 25(OH)D levels and SARS-CoV-2 infection and mortality per million of the population.

Results

An inverse correlation was observed between the mean level of 25(OH)D and SARS-CoV-2 infection rate (r= -0.43, p= 0.02) and mortality rate (r= -0.42, p= 0.02).

Conclusions

The present observational study revealed an association of vitamin D with SARS-CoV-2 infection and related mortality. Further studies are required to validate our observations.



中文翻译:

一项观察性研究表明,维生素D水平较低与印度人SARS-CoV-2感染和死亡率相关

背景

维生素D在各种病毒性疾病的易感性和严重性中的作用已得到充分证明。最近,一些报道强调了维生素D在严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)中的重要性。尽管印度全年都有充足的阳光,但大多数印度人维生素D水平不足。在本研究中,我们假设维生素D缺乏将与印度人口中的SARS-CoV-2感染率和死亡率相关。

材料和方法

SARS-CoV-2感染和死亡率数据来自印度政府的官方网站(于2020年8月16访问)。搜索了各种文献数据库,如PubMed和Google Scholar,以查找印度不同州和工会地区25-羟基维生素D [25(OH)D]水平的平均值,进行了Pearson相关性研究,以探讨平均值25( OH)D水平以及SARS-CoV-2感染和每百万人口的死亡率。

结果

观察到25(OH)D的平均水平与SARS-CoV-2感染率(r = -0.43,p = 0.02)和死亡率(r = -0.42,p = 0.02)之间呈负相关。

结论

本观察性研究表明维生素D与SARS-CoV-2感染和相关死亡率有关。需要进一步研究以验证我们的观察结果。

更新日期:2020-09-15
down
wechat
bug