Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial role of intracellular metabolism in regulating immune cell function. Emerging insights into how systemic inflammation and metabolism influence each other provide a critical additional dimension on the organismal level. Here, we discuss the concept of systemic immunometabolism and review the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in inflammatory and infectious diseases, as well as how these mechanisms apply to homeostasis. We present current challenges of systemic immunometabolic research, and in this context, highlight opportunities and put forward ideas to effectively explore organismal physiological complexity in both health and disease.

在过去的 10 年里，免疫代谢领域取得了长足的进步，揭示了细胞内代谢在调节免疫细胞功能中的关键作用。对全身性炎症和新陈代谢如何相互影响的新见解在有机体水平上提供了一个重要的额外维度。在这里，我们讨论了全身免疫代谢的概念，并回顾了目前对作为全身炎症和炎症和传染病中器官代谢相互影响基础的通信回路的理解，以及这些机制如何应用于体内平衡。我们介绍了系统免疫代谢研究当前面临的挑战，并在此背景下强调机会并提出想法，以有效探索健康和疾病中的有机体生理复杂性。