Abstract Carbohydrate multivalent interactions play a key role in nature as efficient recognition tools for controlling a plethora of physiological and pathological events. These interactions are weak but the presence of multiple copies of ligands and receptors on biological surfaces leads to a multivalent recognition with enhanced selectivity and exponentially increased affinity. Here we report a simple and straightforward methodology for multivalent presentation of both simple monosaccharide ligands and complex dendritic glycostructures using polymeric nanogels (NGs). The interaction between the glycoNGs and a model lectin has been analysed by DLS and UV–Vis agglutination assays, showing that the introduction of glycodendrons with 3 and 9 mannose residues into the NGs results in a strong enhancement of the multivalency.

中文翻译：

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Glyconanogels 作为碳水化合物多价呈现的多功能平台：从单糖到树枝状糖结构

摘要 碳水化合物多价相互作用在自然界中起着关键作用，作为控制大量生理和病理事件的有效识别工具。这些相互作用很弱，但生物表面上存在多拷贝的配体和受体导致多价识别具有增强的选择性和指数增加的亲和力。在这里，我们报告了一种简单直接的方法，用于使用聚合物纳米凝胶 (NG) 对简单单糖配体和复杂树突糖结构进行多价呈现。已经通过 DLS 和 UV-Vis 凝集测定分析了 glycoNGs 和模型凝集素之间的相互作用，表明将具有 3 和 9 个甘露糖残基的糖苷元引入 NG 导致多价性的强烈增强。