BACKGROUND Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS Published studies concerned association between IL12B rs10045431, rs6887695 polymorphisms and IBD were searched from the Wiley Online Library, PubMed, Web of Science and the CNKI database. The odds ratio (OR) with 95% confidence interval (CI) was calculated to evaluate the strength of the relationship. The false positive report probabilities (FPRPs) test and trial sequential analysis (TSA) was performed to investigated the reliability of results. RESULTS A total of 20 studies comprising 10761 Crohn's disease (CD), 10921 ulcerative colitis (UC) and 18381 controls were included in this meta-analysis. Overall, the pooled results showed that IL12B rs6887695 polymorphism significantly increased both CD and UC risk under all model, while IL12B rs10045431 polymorphism dramatically decreased both CD and UC risk under all model. FPRP and TSA demonstrated that above associations was confirmed in the present study. CONCLUSION The results of meta-analysis indicate IL12B rs10045431 and rs6887695 polymorphisms significantly associate with IBD in Caucasian population.

中文翻译：

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白种人 IL12B 多态性与炎症性肠病的相关性：荟萃分析

背景 已发表的关于白种人人群中 IL12B (G/A) rs10045431、(T/C)rs6887695 多态性与炎症性肠病 (IBD) 风险之间关联的研究产生了相互矛盾的结果。本研究的目的是通过进行荟萃分析可能提供更可靠的结论。方法 从 Wiley 在线图书馆、PubMed、Web of Science 和 CNKI 数据库中检索有关 IL12B rs10045431、rs6887695 多态性与 IBD 之间关联的已发表研究。计算具有 95% 置信区间 (CI) 的优势比 (OR) 以评估关系的强度。进行了假阳性报告概率 (FPRPs) 测试和试验序列分析 (TSA) 以研究结果的可靠性。结果 总共 20 项研究，包括 10761 克罗恩病 (CD)，该荟萃分析包括 10921 名溃疡性结肠炎 (UC) 和 18381 名对照。总体而言，汇总结果表明，IL12B rs6887695 多态性在所有模型下均显着增加了 CD 和 UC 风险，而 IL12B rs10045431 多态性在所有模型下均显着降低了 CD 和 UC 风险。FPRP 和 TSA 证明上述关联在本研究中得到证实。结论荟萃分析结果表明IL12B rs10045431 和rs6887695 多态性与白种人人群的IBD 显着相关。FPRP 和 TSA 证明上述关联在本研究中得到证实。结论荟萃分析结果表明IL12B rs10045431 和rs6887695 多态性与白种人人群的IBD 显着相关。FPRP 和 TSA 证明上述关联在本研究中得到证实。结论荟萃分析结果表明IL12B rs10045431 和rs6887695 多态性与白种人人群的IBD 显着相关。