Abstract

Both male and female Wistar rats with an experimental model of autism spectrum disorders induced by prenatal administration of valproate sodium at a dose of 500 mg/kg have behavioral abnormalities similar to people with these disorders, including the abnormalities of social interaction; locomotor, orientation, and exploratory behavior; coordination of movement; spatial exploration behavior; and hyperactivity in previously explored “familiar” environments. The severity of behavioral abnormalities in rats with fetal valproate syndrome exhibits sex differences, which must be taken into account when conducting experimental studies in this model.

中文翻译：

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胎儿丙戊酸综合征大鼠的性别特异性行为特征

摘要

雄性和雌性Wistar大鼠均具有以产前服用丙戊酸钠500 mg / kg诱发的自闭症谱系障碍实验模型，其行为异常与患有这些障碍的人相似，包括社交互动异常；运动，方向和探索行为；运动协调；空间探索行为；和以前探索过的“熟悉”环境中的过度活跃。胎儿丙戊酸综合征大鼠行为异常的严重程度表现出性别差异，在进行该模型的实验研究时必须考虑到这一点。