Abstract

Eight new peroxo complexes of the type [MO(O₂)(Asp)L] have been synthesized and characterized by conductivity, magnetic moments, UV-Vis, IR, ESI-MS and ¹H NMR spectra, TLC, and elemental analyses [M = Th(IV) and Zr(IV), Asp= deprotonated aspartic acid, L = quinoline, isoquinoline, 8-hydroxyquinoline, and 1,10-phenanthroline]. IR spectra indicate that the ligands coordinate to the metal ions via nitrogen of the amino group of aspartic acid and heterocyclic amines, oxygen of the carboxylate group of deprotonated aspartic acid and the peroxo group (O–O). ESI-MS spectral data and magnetic moment values coupled with electronic spectral data suggest an octahedral geometry for all the complexes. The molar conductance values indicate that all the complexes behave as 1 : 2 electrolytes except complexes of 8-hydroxyquinoline that behaves as 1 : 3 electrolytes. Antibacterial activity of the complexes has been tested against four pathogenic bacteria, two Gram-positive Staphylococcus aureus and Bacillus subtilis and two Gram-negative Escherichia coli and Shigella dysenteriae using Kanamycin (K-30) as a standard. The MIC values for complexes hve been measured. Antifungal activity of the complexes has been tested against four pathogenic fungi Aspergillus flavus, Penicillium species, Candida species, and Aspergillus niger using Fluconazole-50 as a standard. The complexes K₂[ThO(O₂)(Asp)(IQ)] and K₂[ZrO(O₂)(Asp)(Q)] demonstrate the highest antibacterial activity, and K₂[ZrO(O₂)(Asp)(1,10-Phen)] exhibits the highest antifungal activity against all the tested pathogens.

中文翻译：

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含天冬氨酸和胺碱的Th（IV）和Zr（IV）离子的过氧配合物作为潜在的生物制剂

摘要

合成了八种[MO（O ₂）（Asp）L]类型的新过氧配合物，并通过电导率，磁矩，UV-Vis，IR，ESI-MS和¹表征1 H NMR谱，TLC和元素分析[M ＝ Th（IV）和Zr（IV），Asp ＝去质子化的天冬氨酸，L ＝喹啉，异喹啉，8-羟基喹啉和1，10-菲咯啉]。红外光谱表明，配体通过天冬氨酸氨基和杂环胺的氮，去质子化天冬氨酸的羧酸根的氧和过氧基（O-O）与金属离子配位。ESI-MS光谱数据和磁矩值再加上电子光谱数据，表明所有配合物的八面体几何形状。摩尔电导值表明，除8-羟基喹啉的络合物为1：3电解质外，所有络合物均以1：2电解质的形式存在。该复合物的抗菌活性已针对四种致病菌进行了测试，其中两种革兰氏阳性金黄色葡萄球菌和枯草芽孢杆菌以及两个革兰氏阴性大肠杆菌和痢疾志贺氏菌，以卡那霉素（K-30）为标准。已经测量了复合物的MIC值。使用Fluconazole-50作为标准品，已测试了该复合物对四种病原真菌黄曲霉，青霉菌种，念珠菌和黑曲霉的抗真菌活性。配合物K ₂ [ThO（O ₂）（Asp）（IQ）]和K ₂ [ZrO（O ₂）（Asp）（Q）]具有最高的抗菌活性，而K ₂ [ZrO（O）₂）（Asp）（1,10-Phen）]对所有测试的病原体均表现出最高的抗真菌活性。