Metastasis is the most life-threatening event in cancer patients, so the key strategy to treat cancer should be preventing tumor spread. Predicting the site of probable hematogenous metastasis is important for determining the therapeutic algorithm that could prevent the spread of tumor cells. Certain hopes for solving this problem appeared owing to study showing the association between specific integrins on tumor exosomes surface and the site of future metastasis. Numerous experimental data indicate the ability of exosomes to transfer various phlogogenic factors to the target organ, which can lead to the formation of inflammatory foci. Studies of T-lymphocytes homing show that expression of various adhesion molecules including ligands for integrins highly increases on the endothelium during inflammation. Such a mechanism underlies not only in leukocyte transvasation, but, apparently, in the accumulation of bone marrow precursor cells and the formation of a premetastatic niche. This review summarizes the most significant data on the role exosomes to induce inflammation, which leads to the recruiting of bone marrow precursors and the establishment of premetastatic niches.

转移是癌症患者中最威胁生命的事件，因此治疗癌症的关键策略应该是预防肿瘤扩散。预测可能的血源性转移的部位对于确定可以防止肿瘤细胞扩散的治疗算法很重要。由于研究表明肿瘤外泌体表面上的特定整合素与未来转移的部位之间存在关联，因此解决该问题的某些希望出现了。许多实验数据表明，外泌体将各种促炎因子转移至靶器官的能力，这可能导致炎症灶的形成。T淋巴细胞归巢的研究表明，炎症过程中，各种粘附分子（包括整联蛋白配体）的表达在内皮细胞上高度增加。这种机制不仅是白细胞转运的基础，而且显然是骨髓前体细胞积累和转移前利基形成的基础。这篇综述总结了外来体在诱导炎症中的作用的最重要数据，这些作用导致募集骨髓前体和建立转移前的利基。