Cellular starvation induced by glucose oxidase (GOx) had been extensively explored as a potential approach for tumor therapy. However, the therapeutic efficacy suffers daunting challenges due to the unsatisfactory intracellular transportation of GOx molecules. Herein for the first time, hydroxide nanoparticles with unique hollow microstructure (denoted as H-NiAl(OH) _x ) were designed and synthesized for GOx delivery. In this system, despite its intrinsic degradation properties in acidic tumor microenvironment, Ni²⁺ ions released during degradation may catalyze a Fenton reaction to induce considerable production of cytotoxic hydroxyl radicals (OH). The cavity of hollow nanocapsules provides large surface area, and favors GOx capsulation and delivery. The findings indicate the intracellular glucose can be effectively consumed by GOx transported, and the reaction products consisting of acid and H₂O₂ facilitate the OH induction of nanocapsules in a synergistic manner. Both in vitro and in vivo antitumor properties have been consequently achieved by H-NiAl(OH) _x /GOx systems. This study offering catalytic nanocapsules based on Ni²⁺ ions may spark a series of follow-on explorations in constructing drug delivery and therapeutic systems for synergistic tumor treatment.

中文翻译：

---

中空的NiAl（OH）x纳米胶囊可实现有效的葡萄糖氧化酶递送和协同治疗。

由葡萄糖氧化酶（GOx）诱导的细胞饥饿已被广泛研究作为一种潜在的肿瘤治疗方法。然而，由于GOx分子的细胞内运输不令人满意，治疗功效遭受了艰巨的挑战。本文首次设计并合成了具有独特中空微观结构的氢氧化物纳米粒子（称为H-NiAl（OH）_x）用于GOx传递。在此系统中，尽管其在酸性肿瘤微环境中具有固有的降解特性，但Ni ²⁺ 降解过程中释放的离子可能会催化Fenton反应，从而诱导大量产生细胞毒性羟基自由基（OH）。中空纳米胶囊的腔体提供了较大的表面积，并有利于GOx的封装和递送。这些发现表明细胞内的葡萄糖可以被GOx运输有效地消耗，并且由酸和H 2 O 2组成的反应产物以协同方式促进了纳米胶囊的OH诱导。二者在体外和体内的抗肿瘤性质已经通过H-NiAl金属（OH）被因此实现_X /葡萄糖氧化酶系统。这项研究提供了基于Ni ^2+的催化纳米胶囊 离子可能会引发一系列后续探索，以构建用于协同肿瘤治疗的药物输送和治疗系统。