Diabetic foot is one of the severest complications of diabetes. In severe cases, this disease may be lead to amputation or even death due to secondary infection and ischemic necrosis. Since the ineffectiveness of traditional therapy, autologous stem cell transplantation has been used to treat diabetic foot. This simple, safe, and effective therapy is expected to be applied and promoted in the future. In this review, we described the detailed pathogenesis of diabetic foot and the common clinical treatments currently used. We also revealed vascular remodeling as the potential mechanism of therapeutic functions of adipose-derived stromal vascular fraction (SVF) in treating diabetic foot.

中文翻译：

---

脂肪来源的基质血管部分在糖尿病足中的治疗应用。

糖尿病足是糖尿病最严重的并发症之一。在严重的情况下，由于继发感染和缺血性坏死，该疾病可能导致截肢甚至死亡。由于传统疗法无效，自体干细胞移植已被用于治疗糖尿病足。这种简单，安全，有效的疗法有望在未来得到应用和推广。在这篇综述中，我们描述了糖尿病足的详细发病机理以及目前使用的常见临床治疗方法。我们还揭示了血管重塑是脂肪来源的基质血管部分（SVF）在治疗糖尿病足中的治疗功能的潜在机制。