Alzheimer’s disease (AD) is a common neurodegenerative disorder without any satisfactory therapeutic approaches. AD is mainly characterized by the deposition of β-amyloid protein (Aβ) and extensive neuronal cell death. Curcumin, with anti-oxidative stress (OS) and cell apoptosis properties, plays essential roles in AD. However, whether bisdemethoxycurcumin (BDMC), a derivative of curcumin, can exert a neuroprotective effect in AD remains to be elucidated.

中文翻译：

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BDMC 通过 AMPK 和 SIRT1 在体外保护 AD

阿尔茨海默病（AD）是一种常见的神经退行性疾病，没有任何令人满意的治疗方法。AD的主要特征是β-淀粉样蛋白（Aβ）的沉积和广泛的神经元细胞死亡。姜黄素具有抗氧化应激 (OS) 和细胞凋亡特性，在 AD 中起重要作用。然而，姜黄素衍生物双去甲氧基姜黄素 (BDMC) 是否可以在 AD 中发挥神经保护作用仍有待阐明。