Blood–brain barrier (BBB) dysfunction and neuroinflammation induced by traumatic brain injuries (TBIs) cause a succession of secondary brain damage events and finally lead to a massive and progressive cerebral neuronal destruction. Artesunate, a semisynthetic artemisinin derivative, is a potential candidate for the management of cerebral damage induced by TBI due to its protective function to BBB and cerebral neurons.

中文翻译：

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青蒿琥酯减轻大鼠创伤性脑损伤引起的损伤

由创伤性脑损伤 (TBI) 引起的血脑屏障 (BBB) 功能障碍和神经炎症会导致一系列继发性脑损伤事件，最终导致大规模和进行性脑神经元破坏。青蒿琥酯是一种半合成青蒿素衍生物，由于其对 BBB 和脑神经元的保护作用，是治疗 TBI 引起的脑损伤的潜在候选药物。