Resveratrol, polyphenol naturally occurring in grapes or nuts, has anti-cancer properties in the treatment of neuroblastoma – the most common childhood solid tumor. It affects cancer cells by increasing apoptosis, inducing cell necrosis and reducing tumor mass. Mechanism of action – (1) converting procaspases, mainly procaspases three and nine into active forms – caspases, (2) blocking kinases, and also (3) leading the cell to the S-cell cycle, where it is most effective while increasing the concentration of cyclin E and lowering the concentration of p21 protein. In vitro, as well as, rodent animal models studies are available and show promising results. Therapeutic doses, currently within 10–100 μmol/L, are also being tested, as well as other forms of resveratrol, such as its trans-4,4′-dihydroxystilbene analog and polyphenol lipoconjugates. In our review, we presented the known molecular mechanisms of polyphenol anti-tumor activity against neuroblastoma and discussed the studies confirming its effectiveness.

中文翻译：

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白藜芦醇治疗神经母细胞瘤：综述。


白藜芦醇是一种天然存在于葡萄或坚果中的多酚，在治疗神经母细胞瘤（最常见的儿童实体瘤）方面具有抗癌特性。它通过增加细胞凋亡、诱导细胞坏死和减少肿瘤质量来影响癌细胞。作用机制 – (1) 将天冬氨酸蛋白酶原（主要是天冬氨酸蛋白酶原 3 和 9）转化为活性形式 – 半胱天冬酶，(2) 阻断激酶，以及 (3) 引导细胞进入 S 细胞周期，在该周期中它最有效，同时增加细胞周期蛋白 E 的浓度并降低 p21 蛋白的浓度。体外以及啮齿动物模型研究都是可行的，并显示出有希望的结果。目前还在测试 10-100 μmol/L 的治疗剂量以及其他形式的白藜芦醇，例如其反式-4,4'-二羟基二苯乙烯类似物和多酚脂结合物。在我们的综述中，我们介绍了多酚抗神经母细胞瘤活性的已知分子机制，并讨论了证实其有效性的研究。