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Biomimetically Mineralized Alginate Nanocomposite Fibers for Bone Tissue Engineering: Mechanical Properties and in Vitro Cellular Interactions
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-09-13 , DOI: 10.1021/acsabm.0c00692 Taesik Chae 1 , Heejae Yang 1 , Haisle Moon 2 , Tom Troczynski 1 , Frank K Ko 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-09-13 , DOI: 10.1021/acsabm.0c00692 Taesik Chae 1 , Heejae Yang 1 , Haisle Moon 2 , Tom Troczynski 1 , Frank K Ko 1
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We report herein the structural and mechanical properties and in vitro cellular response of hydroxyapatite (HAp)/alginate nanocomposite fibrous scaffolds mimicking the mineralized collagen fibrils of bone tissue. The biomimetically “engineered” nanocomposites, fabricated by electrospinning and in situ synthesis strategy, were compared with pure alginate nanofibers and micrometer-level HAp/alginate composite fibers. The tensile strength and elastic modulus of the nanocomposites increased by 79.3 and 158.4%, respectively, compared to those of alginate. The uniform nucleation and HAp nanocrystal growth on the alginate nanofibers resulted in such enhancement of the mechanical properties via a stress-transfer effect. Rat calvarial osteoblasts were stably attached and stretched more extensively on the nanocomposites’ surface than on the pristine alginate. The controlled deposition of the HAp nanophase contributed to a much faster cell proliferation rate on the nanocomposites than on the others. The improved structural stability and osteoblast interactions suggest the fibrous nanocomposite scaffold’s potential advantages for bone tissue regeneration.
中文翻译：
用于骨组织工程的仿生矿化藻酸盐纳米复合纤维：机械性能和体外细胞相互作用
我们在此报告了模拟骨组织矿化胶原纤维的羟基磷灰石 (HAp)/藻酸盐纳米复合纤维支架的结构和机械性能以及体外细胞反应。仿生“工程”将通过静电纺丝和原位合成策略制造的纳米复合材料与纯藻酸盐纳米纤维和微米级HAp/藻酸盐复合纤维进行了比较。与海藻酸盐相比，纳米复合材料的拉伸强度和弹性模量分别提高了 79.3% 和 158.4%。藻酸盐纳米纤维上的均匀成核和 HAp 纳米晶体生长通过应力传递效应导致机械性能的这种增强。与原始海藻酸盐相比，大鼠颅骨成骨细胞在纳米复合材料表面上更稳定地附着和伸展。HAp 纳米相的受控沉积有助于纳米复合材料上的细胞增殖速度比其他复合材料上快得多。
更新日期：2020-10-21
中文翻译：
用于骨组织工程的仿生矿化藻酸盐纳米复合纤维：机械性能和体外细胞相互作用
我们在此报告了模拟骨组织矿化胶原纤维的羟基磷灰石 (HAp)/藻酸盐纳米复合纤维支架的结构和机械性能以及体外细胞反应。仿生“工程”将通过静电纺丝和原位合成策略制造的纳米复合材料与纯藻酸盐纳米纤维和微米级HAp/藻酸盐复合纤维进行了比较。与海藻酸盐相比，纳米复合材料的拉伸强度和弹性模量分别提高了 79.3% 和 158.4%。藻酸盐纳米纤维上的均匀成核和 HAp 纳米晶体生长通过应力传递效应导致机械性能的这种增强。与原始海藻酸盐相比，大鼠颅骨成骨细胞在纳米复合材料表面上更稳定地附着和伸展。HAp 纳米相的受控沉积有助于纳米复合材料上的细胞增殖速度比其他复合材料上快得多。
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