Abstract

Aim

This study aimed to investigate the genomic diversity and population structure in the Muslim community of Telangana, India, using 23 autosomal microsatellite genetic markers. We also examined genetic relatedness between Muslim and non-Muslim populations of India.

Subjects and methods

A sample of 184 randomly selected unrelated healthy Muslim individuals from the Telangana state were included in this study. The genotyping of 23 autosomal STR markers included in PowerPlex^® Fusion 6 C multiplex system (Promega)was done.

Results

A total of 273 alleles were observed in the studied population, and locus SE33 showed 37 observed alleles, which is the highest number of observed alleles among all the studied loci. Among all the studied loci the most polymorphic and discriminatory locus was SE33, with the values of polymorphic information content (PIC) = 9.411E–01 and power of discrimination (PD) = 9.865E–01. Observed heterozygosity ranged from 6.630E–01 (D22S1045) to 9.239E–01 (SE33). Discrimination power, exclusion power, matching probability and paternity index for all the studied loci were 1.00E + 00, 1.00E + 00, 2.01E–28, and 5.68E + 09, respectively. The studied Muslim population showed genetic relatedness with non-Muslim populations i.e. populations of central India, Jharkhand, and Uttar Pradesh, suggesting the conversion of Hindus during the Muslim invasion.

Conclusion

Neighbor-joining (NJ) tree and principal component analysis (PCA) revealed that the studied population showed genetic affinity with communities of Jharkhand, Madhya Pradesh and Uttar Pradesh states. The genetic data of this study may be useful for forensic, medical, and anthropological studies.

中文翻译：

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从23个常染色体STR推断出来自Telangana（印度）的穆斯林人口的基因组多样性。

摘要

目标

这项研究旨在利用23种常染色体微卫星遗传标记研究印度特兰甘纳邦穆斯林社区的基因组多样性和种群结构。我们还研究了印度穆斯林和非穆斯林人口之间的遗传相关性。

主题与方法

这项研究包括来自Telangana州的184名随机选择的不相关健康穆斯林个体的样本。的包括在23的PowerPlex常染色体STR标记基因分型^®融合6个C复用系统（Promega）中已完成。

结果

在研究人群中总共观察到273个等位基因，并且SE33位点显示了37个观察到的等位基因，这是所有研究基因座中观察到的等位基因数量最多的地方。在所有研究的基因座中，最具有多态性和歧视性的基因座是SE33，其多态信息含量（PIC）= 9.411E-01，判别力（PD）= 9.865E-01。观察到的杂合度范围为6.630E-01（D22S1045）至9.239E-01（SE33）。所有研究位点的识别力，排斥力，匹配概率和亲子指数分别为1.00E + 00、1.00E + 00、2.01E–28和5.68E + 09。所研究的穆斯林人口与非穆斯林人口（即印度中部，贾坎德邦和北方邦的人口）具有遗传相关性，这表明在穆斯林入侵期间印度教徒conversion依。

结论

邻近树（NJ）和主成分分析（PCA）表明，所研究的种群与贾坎德邦，中央邦和北方邦的社区具有遗传亲和力。这项研究的遗传数据可能对法医，医学和人类学研究有用。