Front cover: Goldfish (Carassius auratus) with the telescope‐eye, dorsal‐fin‐loss or long‐tail phenotype are swimming calmly in a large fishbowl followed by chromosomes. Goldfish experienced a whole‐genome duplication 8‐14 million years ago, making it difficult to analyze its genome, but finally the genome sequences of various varieties were sequenced and the causative genes (candidates) of these traits were also found. Among these, the causative gene (candidate) for long‐tail, kcnk5bS, encodes a K⁺ channel as depicted on the side of the bowl. This research is expected to be applicable to the study of vertebrate morphogenesis and human disorders. See Chen et al. (2019) Science Advances 5: eaav0547 and Kon et al. (2020) Current Biology 30: 2260‐2274 for further detail. We thank Prof. Yoshihiro Omori (Nagahama Institute of Bio‐science and Technology) for his advice on drawing. Designed by TRAIS Co., Ltd. (Kobe, Japan).

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发行信息

封面：带有望远镜眼，背鳍损失或长尾表型的金鱼（Car鱼）在一个大鱼缸中平静地游泳，随后是染色体。金鱼在8-14百万年前经历了全基因组复制，使其基因组分析变得困难，但最终对各种变种的基因组序列进行了测序，并发现了这些性状的致病基因（候选）。其中，长尾的致病基因（候选基因）kcnk5bS编码碗侧面所示的K ⁺通道。该研究有望适用于脊椎动物形态发生和人类疾病的研究。参见Chen等。（2019）科学进展5：eaav0547和Kon等。（2020）Current Biology 30：2260-2274了解更多信息。我们感谢长滨生物科学技术学院的大森义弘教授对绘画的建议。由TRAIS有限公司（日本神户）设计。