Poly(2‐oxazoline)s have excellent biocompatibility and have been used as FDA‐approved indirect food additives. The inert property of the hydrophilic poly(2‐oxazoline)s suggests them as promising substitutes for poly(ethylene glycol) (PEG) in various applications such as anti‐biofouling agents. It was recently reported that poly(2‐oxazoline)s themselves have antimicrobial properties as synthetic mimics of host defense peptides. These studies revealed the bioactive properties of poly(2‐oxazoline)s as a new class of functional peptide mimics, by mimicking host defense peptides to display potent and selective antimicrobial activities against methicillin‐resistant Staphylococcus aureus both in vitro and in vivo, without concerns about antimicrobial resistance. The high structural diversity, facile synthesis, and potent and tunable antimicrobial properties underscore the great potential of poly(2‐oxazoline)s as a class of novel antimicrobial agents in dealing with drug‐resistant microbial infections and antimicrobial resistance.

中文翻译：

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肽模拟聚（2-恶唑啉）显示有效的抗菌特性。

聚（2-恶唑啉）具有优异的生物相容性，已被用作 FDA 批准的间接食品添加剂。亲水性聚（2-恶唑啉）的惰性表明它们在抗生物污垢剂等各种应用中是聚乙二醇（PEG）的有前途的替代品。最近有报道称，聚（2-恶唑啉）本身作为宿主防御肽的合成模拟物具有抗菌特性。这些研究揭示的聚（2-恶唑啉）S作为一类新的功能性肽模拟物，的生物活性性质通过模仿宿主防御肽显示对耐甲氧西林有效的和选择性的抗微生物活性的金黄色葡萄球菌都在体外和体内，无需担心抗菌素耐药性。高度的结构多样性、易于合成以及有效且可调节的抗菌特性强调了聚（2-恶唑啉）作为一类新型抗菌剂在应对耐药微生物感染和抗菌素耐药性方面的巨大潜力。