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An Antioxidant Enzyme Therapeutic for COVID-19.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-09-13 , DOI: 10.1002/adma.202004901 Meng Qin 1 , Zheng Cao 2 , Jing Wen 2 , Qingsong Yu 1 , Chaoyong Liu 1 , Fang Wang 1 , Jianjun Zhang 1 , Fengmei Yang 3 , Yanyan Li 3 , Gregory Fishbein 2 , Sen Yan 4 , Bin Xu 2 , Yi Hou 1 , Zhenbo Ning 1 , Kaili Nie 1 , Ni Jiang 1 , Zhen Liu 1 , Jun Wu 1 , Yanting Yu 1 , Heng Li 3 , Huiwen Zheng 3 , Jing Li 3 , Weihua Jin 3 , Shen Pang 5 , Shuai Wang 5 , Jianfeng Chen 1 , Zhihua Gan 1 , Zhanlong He 3 , Yunfeng Lu 2
Advanced Materials ( IF 27.4 ) Pub Date : 2020-09-13 , DOI: 10.1002/adma.202004901 Meng Qin 1 , Zheng Cao 2 , Jing Wen 2 , Qingsong Yu 1 , Chaoyong Liu 1 , Fang Wang 1 , Jianjun Zhang 1 , Fengmei Yang 3 , Yanyan Li 3 , Gregory Fishbein 2 , Sen Yan 4 , Bin Xu 2 , Yi Hou 1 , Zhenbo Ning 1 , Kaili Nie 1 , Ni Jiang 1 , Zhen Liu 1 , Jun Wu 1 , Yanting Yu 1 , Heng Li 3 , Huiwen Zheng 3 , Jing Li 3 , Weihua Jin 3 , Shen Pang 5 , Shuai Wang 5 , Jianfeng Chen 1 , Zhihua Gan 1 , Zhanlong He 3 , Yunfeng Lu 2
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The COVID‐19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process, is reported. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS‐CoV‐2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID‐19.
中文翻译：
COVID-19的抗氧化酶治疗剂。
COVID-19大流行给全世界的人们造成了巨大的损失，目前还没有特定的抗病毒药物或疫苗。在本文中，它是基于过氧化氢酶的治疗剂，据报道，该抗氧化酶可以有效地分解过氧化氢并最小化由于感染和炎性过程而过度产生的下游活性氧种类。过氧化氢酶有助于调节细胞因子的产生，保护氧化损伤并抑制SARS-CoV-2的复制，这在人白细胞和肺泡上皮细胞以及恒河猴中均表现出来，而没有明显的毒性。作为COVID-19的潜在疗法，这种疗法很容易以低成本制造。
更新日期：2020-10-26
中文翻译：
COVID-19的抗氧化酶治疗剂。
COVID-19大流行给全世界的人们造成了巨大的损失，目前还没有特定的抗病毒药物或疫苗。在本文中，它是基于过氧化氢酶的治疗剂，据报道，该抗氧化酶可以有效地分解过氧化氢并最小化由于感染和炎性过程而过度产生的下游活性氧种类。过氧化氢酶有助于调节细胞因子的产生，保护氧化损伤并抑制SARS-CoV-2的复制，这在人白细胞和肺泡上皮细胞以及恒河猴中均表现出来，而没有明显的毒性。作为COVID-19的潜在疗法，这种疗法很容易以低成本制造。
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