The objective of this study is to evaluate the solubility of an enteric polymer, Eudragit L100, in a supercritical CO₂-ethanol mixture, and to produce spherical microcapsules for phenylalanine using Eudragit L100 as the coating substance by the PGSS process both at temperature 50 °C and pressures from 8 to 12 MPa. The average particle size obtained from the particles from gas saturated solution (PGSS) process decreased from 200.9 μm ± 20.5 μm to 140.6 μm ± 40.1 μm with increasing pressure from 8 to 12 MPa. The highest encapsulation efficiency of 68 ± 7% was obtained from the microcapsules produced from PGSS conducted at 50 ℃ and 10 MPa which SEM observation confirmed spherical microcapsules without aggregation. Sustained drug release assay of the microcapsules showed a sustained and enhanced drug release at low and high pH conditions, respectively, indicating successful micro coating of phenylalanine by Eudragit L100.

这项研究的目的是评估肠溶性聚合物Eudragit L100在超临界CO _2-乙醇混合物中的溶解度，并使用Eudragit L100作为包衣物质，通过PGSS工艺在50°C的温度下生产用于苯丙氨酸的球形微胶囊。 C和8至12 MPa的压力。从气体饱和溶液（PGSS）过程中从颗粒得到的平均粒径为200.9减小 μ米±20.5  μ m至140.6  μ米±40.1  μ压力从8 MPa增加到12 MPa。由PGSS在50℃和10 MPa下进行制备的微囊的最高包封效率为68±7％，SEM观察证实球形微囊没有聚集。微胶囊的持续药物释放测定分别显示了在低和高pH条件下药物的持续释放和增强释放，表明Eudragit L100成功地微包被了苯丙氨酸。