Propolis (bee glue) is a bee glue, sticky resinous material released from various plant sources such as bud exudates, flowers, and leaves modified by bee secretions and wax propolis is composed of resins, waxes, polyphenols, polysaccharides, volatile materials, and secondary metabolites that are responsible for various bioactivity such as antibacterial, anti-angiogenic, antiulcer, anti-inflammatory, antioxidant, and anti-viral activities. The physico-chemical characteristics and the natural properties of various kinds of propolis have been studied for the past decade. Novel active anti-microbial compounds have been identified in propolis. Those compounds positively modulated the antimicrobial resistance of multidrug resistant bacteria. Published research has indicated that propolis and its derivatives has many natural antimicrobial compounds with a broad spectrum against different types of bacteria and that it enhanced the efficacy of conventional antibiotics. Besides, the combination of propolis with other compounds such as honey has been studied whereby, such combinations have a synergistic effect against bacterial strains such as Escherichia coli and Staphylococcus aureus. The activity of propolis is very much dependent on seasonal and regional factors, and Middle Eastern propolis have shown best antibacterial efficacy. Propolis and its main flavonoids ingredients should not be overlooked and should be evaluated in clinical trials to better elucidate their potential application in various fields of medicine. Clinical antibacterial potential and its use in new drugs of biotechnological products should be conducted. This review aims at highlighting some of the recent scientific findings associated with the antibacterial properties of propolis and its components.

蜂胶（蜂胶）是一种蜂胶，是从各种植物源中释放的粘性树脂材料，例如由蜂分泌物和蜡改性的芽分泌物，花朵和叶子。蜂胶由树脂，蜡，多酚，多糖，挥发性物质和次要成分组成负责各种生物活性的代谢物，例如抗菌，抗血管生成，抗溃疡，抗炎，抗氧化剂和抗病毒活性。在过去的十年中，已经研究了各种蜂胶的理化特性和自然特性。在蜂胶中已鉴定出新型的活性抗微生物化合物。这些化合物积极地调节了耐多药细菌的抗药性。公开的研究表明，蜂胶及其衍生物具有多种天然抗菌化合物，具有针对不同类型细菌的广谱性，并且增强了常规抗生素的功效。此外，已经研究了蜂胶与其他化合物如蜂蜜的组合，由此，这种组合对细菌菌株如细菌具有协同作用。大肠杆菌和金黄色葡萄球菌。蜂胶的活性在很大程度上取决于季节和区域因素，并且中东蜂胶已显示出最佳的抗菌功效。蜂胶及其主要类黄酮成分不容忽视，应在临床试验中进行评估，以更好地阐明其在医学各个领域的潜在应用。应当进行临床抗菌潜力及其在生物技术产品新药中的使用。这篇综述旨在强调蜂胶及其成分的抗菌特性相关的一些最新科学发现。