Abstract Shape memory polyurethanes (SMPUs) have attracted much attention in the biomedical field because they can easily control the transition temperature (Ttrans) to shape memory and are biocompatible. In this study, a shape memory polyurethane with both biocompatibility and a Ttrans close to the body temperature was synthesized by using natural derivatives of isosorbide and castor oil in place of petroleum-based materials. Isosorbide and castor oil were used to form net points, and polycaprolactone diol (PCL diol) acted as the switching segment. The synthesized four polyurethane (PCL diol/isosorbide/castor oil, PICU-1, 2, 3, 4) with different isosorbide contents exhibited desired thermal and mechanical properties. In the thermo-cyclic shape memory testing experiment, the PICU series demonstrated good shape memory property, with more than 95% shape recovery ratio (Rr) and more than 90% shape fixity ratio (Rf), and PICU-3 recovered its shape within 20 s in a 37 °C water bath. In addition, the PICU series proved to be safe materials with excellent biocompatibility, as indicated by the observed C2C12 cells viability and proliferation. The stent made with the PICU-3 film showed near complete magnetization at 37 °C within 18 s and proved to be a suitable self-expanding stent.

中文翻译：

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异山梨醇和蓖麻油制备具有生物相容性的体温触发形状记忆聚氨酯

摘要 形状记忆聚氨酯（SMPUs）因其易于控制转变温度（Ttrans）以实现形状记忆且具有生物相容性而在生物医学领域备受关注。在这项研究中，通过使用异山梨醇和蓖麻油的天然衍生物代替石油基材料合成了一种具有生物相容性和接近体温的 Ttrans 的形状记忆聚氨酯。异山梨醇和蓖麻油形成网点，聚己内酯二醇（PCL二醇）作为转换段。合成的具有不同异山梨醇含量的四种聚氨酯（PCL二醇/异山梨醇/蓖麻油，PICU-1、2、3、4）表现出所需的热性能和机械性能。在热循环形状记忆测试实验中，PICU系列表现出良好的形状记忆性能，具有超过 95% 的形状恢复率 (Rr) 和超过 90% 的形状固定率 (Rf)，并且 PICU-3 在 37°C 水浴中在 20 秒内恢复了其形状。此外，正如观察到的 C2C12 细胞活力和增殖所表明的那样，PICU 系列被证明是具有优异生物相容性的安全材料。用 PICU-3 薄膜制成的支架在 18 s 内在 37°C 下表现出接近完全的磁化，并被证明是一种合适的自膨式支架。