Background

There is a desperate need for in-vivo behavioral screening tests for anti-manic effects. The frequently used psychostimulant-induced hyperactivity test appears to have lower validity than previously described, but other quick, simple and high throughput tests are currently unavailable.

New method

In the context of modeling the behavioral facets of mania, we previously suggested that the sweet solution preference test (SSP) in naive mice might have predictive validity for screening anti-manic effects. The current study further examined this proposal by testing the effects of lithium, valproate and imipramine on SSP in three strains of mice (male mice from the black Swiss, ICR and C57bl/6 strains) and an exploratory test in females (black Swiss strain).

Results

Data demonstrate that lithium and valproate at appropriate dosing schedules significantly and reliably reduce SSP in all three strains (including in females) but that the antidepressant imipramine has no effects.

Comparison with existing methods

The results support the utilization of the SSP as mice screening model for anti-manic effects of drugs with stronger predictive validity compared with other methods.

Conclusions

The SSP is not a comprehensive model for bipolar disorder but it has good predictive validity and strong practical value that can be applied towards simple and fast screening of large numbers of animals, without the need for specialized equipment or complicated/prolonged procedures. We therefore propose that the SSP is an advantageous screening assay for testing novel mood stabilizing drugs for anti-manic properties.

中文翻译：

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提出将甜味剂偏好测试作为情绪稳定剂抗躁狂作用的筛选试验。

背景

迫切需要体内行为筛查测试以防躁狂。频繁使用的精神兴奋剂诱发的活动亢进测试似乎比先前描述的有效性低，但是目前尚无其他快速，简单和高通量的测试。

新方法

在对躁狂症行为方面进行建模的背景下，我们以前曾提出过，在幼稚小鼠中进行甜味溶液偏爱测试（SSP）可能具有筛选抗躁狂作用的预测有效性。当前的研究通过测试三种品系（黑瑞士种，ICR和C57bl / 6品系的雄性小鼠）中的锂，丙戊酸和丙咪嗪对SSP的作用以及女性（黑种瑞士品系）的探索性试验，进一步检验了该提议。 。

结果

数据表明，在适当的给药方案下，锂和丙戊酸显着且可靠地降低了所有三种菌株（包括雌性菌株）中的SSP，但抗抑郁药丙咪嗪没有作用。

与现有方法的比较

该结果支持将SSP用作小鼠抗躁狂作用筛选模型，与其他方法相比具有更强的预测效度。

结论

SSP并不是双相情感障碍的综合模型，但它具有良好的预测效度和很强的实用价值，可用于简单快速的筛查大量动物，而无需专用设备或复杂/长时间的程序。因此，我们建议SSP是用于测试新型抗情绪躁狂稳定药物的有利筛选方法。