Bisphenol A (BPA), an endocrine-disrupting chemical, has been used as a basic raw material for the production of polycarbonate plastics. As concern over the toxic effects of BPA grows, it is gradually being replaced in many consumer products with compounds such as bisphenol F (BPF) and bisphenol S (BPS). In this study, online solid-phase extraction-high-performance liquid chromatography-tandem mass spectrometry was used to analyze the urinary concentrations of BPA, BPF, and BPS in 2487 Korean urine samples collected between 2017 and 2018. The detection rates and geometric mean (GM) concentrations were as follows: BPA (82.1 %; 0.65 μg/L), BPF (11.1 %; not calculated), and BPS (63.6 %; 0.20 μg/L), respectively. The mean daily intake based on urinary BPA concentrations was 0.013 μg/kg bw/day (95th percentile, 0.089 μg/kg bw/day), which is lower than the tolerable daily intake. This is the first study observing urinary BPA, BPF, and BPS concentrations based on a nationally representative Korean population and could contribute to the evaluation of bisphenol analogue exposure levels in risk assessments.

破坏内分泌的化学物质双酚A（BPA）已用作生产聚碳酸酯塑料的基本原料。随着人们越来越关注BPA的毒性，在许多消费产品中逐渐将其替换为双酚F（BPF）和双酚S（BPS）等化合物。在这项研究中，使用在线固相萃取-高效液相色谱-串联质谱法分析了2017年至2018年收集的2487份韩国尿液样本中的BPA，BPF和BPS尿液浓度。检出率和几何平均值（GM）浓度如下：分别为BPA（82.1％; 0.65μg/ L），BPF（11.1％；未计算）和BPS（63.6％; 0.20μg/ L）。根据尿液BPA浓度计算的平均每日摄入量为0.013μg/ kg bw /天（95％，0.089μg/ kg bw /天），低于每日容许摄入量。这是第一项基于全国代表性的韩国人群观察尿液中BPA，BPF和BPS浓度的研究，可有助于在风险评估中评估双酚类似物的暴露水平。