The goals of this work were to evaluate the effects produced by a hyperglycidic diet (HD) on Drosophila melanogaster and to verify the protective effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) on this model. Adult flies were divided into eight groups of 50 flies each: (1) RD, (regular diet) (2) RD + 4-PSQ (25 μM), (3) HD 5%, (4) HD 10%, (5) HD 30% (6) HD 5% + 4-PSQ (25 μM), (7) HD 10% + 4-PSQ (25 μM) and (8) HD 30% + 4-PSQ (25 μM). Flies were exposed to a diet containing sucrose and or 4-PSQ for ten days, according to each group. At the end of treatment survival rate, longevity, hatch rate, food intake, glucose and triglyceride levels, as well as, some markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and catalase (CAT) activities, protein thiol (PSH) and non-protein levels (NPSH) and cell viability assays (Resazurin and MTT) were evaluated. It was observed that HD's consumption was associated with lower survival of the flies, lower longevity, and increased levels of glucose, triglycerides, TBARS and increased SOD activities and CAT activities. Treatment with 25 μM 4-PSQ increased the satiety of flies, increased survival, reduced glucose, triglyceride and TBARS levels, increased hatching, and normalized SOD and CAT activities. These results suggest that 25 μM 4-PSQ had a potential antioxidant effect and provided greater satiety by attenuating the effects of high HD consumption on this model.

这项工作的目的是评估高糖饮食（HD）对黑腹果蝇产生的影响并验证了7-氯-4-（苯基硒基）喹啉（4-PSQ）对这种模型的保护作用。成年苍蝇分为八组，每组五十只苍蝇：（1）RD，（常规饮食）（2）RD + 4-PSQ（25μM），（3）HD 5％，（4）HD 10％，（5 ）HD 30％（6）HD 5％+ 4-PSQ（25μM），（7）HD 10％+ 4-PSQ（25μM）和（8）HD 30％+ 4-PSQ（25μM）。根据每组，将果蝇暴露于含蔗糖和4-PSQ的饮食中10天。在治疗结束时，存活率，寿命，孵化率，食物摄入，葡萄糖和甘油三酸酯水平以及一些氧化应激指标，例如硫代巴比妥酸反应性物质（TBARS），超氧化物歧化酶（SOD）和过氧化氢酶（CAT） ）活性，蛋白硫醇（PSH）和非蛋白水平（NPSH）以及细胞活力测定（刃天青和MTT）进行了评估。据观察，HD' 食用与果蝇存活率降低，寿命降低以及葡萄糖，甘油三酸酯，TBARS水平升高以及SOD和CAT活性升高有关。用25μM4-PSQ处理可提高果蝇的饱腹感，提高生存率，降低葡萄糖，甘油三酸酯和TBARS的水​​平，增加孵化率并使SOD和CAT活性正常化。这些结果表明25μM4-PSQ具有潜在的抗氧化作用，并且通过减弱高HD消耗对该模型的影响而提供了更高的饱腹感。以及标准化的SOD和CAT活动。这些结果表明25μM4-PSQ具有潜在的抗氧化作用，并且通过减弱高HD消耗对该模型的影响而提供了更高的饱腹感。以及标准化的SOD和CAT活动。这些结果表明25μM4-PSQ具有潜在的抗氧化作用，并且通过减弱高HD消耗对该模型的影响而提供了更高的饱腹感。