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SETting Up for Epigenetic Regulation of Advanced Prostate Cancer.
Cancer Cell ( IF 50.3 ) Pub Date : 2020-09-14 , DOI: 10.1016/j.ccell.2020.08.009 Phillip Thienger 1 , Mark A Rubin 2
中文翻译:
为晚期前列腺癌的表观遗传调控做好准备。
更新日期:2020-09-14
Cancer Cell ( IF 50.3 ) Pub Date : 2020-09-14 , DOI: 10.1016/j.ccell.2020.08.009 Phillip Thienger 1 , Mark A Rubin 2
Affiliation
An outgrowth of therapy-resistant prostate cancers (PCa) with enhanced metastatic potential may be triggered by inhibitors of androgen receptor (AR) signaling, often via epigenetic rewiring. In this issue of Cancer Cell, Yuan et al. demonstrate how SETD2 integrates EZH2 and AMPK signaling pathways to keep PCa metastasis in check.
中文翻译:
为晚期前列腺癌的表观遗传调控做好准备。
具有增强转移潜能的治疗抵抗性前列腺癌 (PCa) 的生长可能是由雄激素受体 (AR) 信号传导抑制剂触发的,通常是通过表观遗传重新布线。在本期Cancer Cell 中,Yuan 等人。展示 SETD2 如何整合 EZH2 和 AMPK 信号通路以控制 PCa 转移。