Amphiphilic block copolymers form self-assembled bilayers even in combination with phospholipids. They represent an attractive alternative to native lipid-based membrane systems for supported bilayer formation with applications in biomedical research, sensoring and drug delivery. Their enhanced stability and excellent mechanical properties are linked to their higher molecular weight which generates thicker bilayers. Hypothesis: It is hypothesized that reducing the molecular weight of the polymer facilitates the formation of a thinner, more homogeneous polymer/lipid hybrid bilayer which would benefit the formation of supported bilayers on silicon oxide. Experiment: We investigated hybrid bilayers composed of mixtures of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine and increasing amounts of a low molecular weight polybutadiene-b-polyethylene oxide copolymer (1050 g/mol). By assessing the bilayer thickness and the molecular packing behavior we sought to demonstrate how reducing the polymer molecular weight increases the tendency to form supported hybrid bilayers in a lipid-like manner. Findings: The formation of a supported hybrid bilayers occurs at polymer contents <70 mol% in a lipid-like fashion and is proportional to the cohesive forces between the bilayer components and inversely related to the bilayer hydrophobic core thickness and the extended brush regime of the PEGylated polymeric headgroup.

两亲性嵌段共聚物甚至与磷脂结合也形成自组装的双层。它们代表了天然脂基膜系统的诱人替代品，可支持双层形成，并应用于生物医学研究，传感和药物输送。它们的增强的稳定性和优异的机械性能与其较高的分子量有关，后者可产生更厚的双层。假设：假设降低聚合物的分子量有助于形成更薄，更均匀的聚合物/脂质杂化双层，这将有利于在氧化硅上形成负载型双层。实验：我们研究了由1-棕榈酰基-2-油酰基-甘油-3-磷酸胆碱和增加量的低分子量聚丁二烯-b-聚环氧乙烷共聚物（1050 g / mol）的混合物组成的混合双层。通过评估双层厚度和分子堆积行为，我们试图证明降低聚合物分子量如何增加以类脂质方式形成支持的杂化双层的趋势。研究结果：负载型杂化双分子层的形成以脂质样方式发生在聚合物含量<70 mol％时，并且与该双分子层成分之间的内聚力成正比，并且与该双分子层的疏水性核芯厚度和该膜的扩展刷涂状态成反比聚乙二醇化的聚合物头基。