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Stimulation of col2a1 Gene Expression with Low-Power Laser Radiation as a Means to Induce Cartilage Formation
Technical Physics ( IF 0.7 ) Pub Date : 2020-09-14 , DOI: 10.1134/s1063784220090091
M. S. Bozhokin , D. B. Vcherashnii , S. G. Yastrebov , L. L. Beilinson , M. G. Khotin

Abstract

Elevated expression of the col2a1 gene responsible for synthesis of type II collagen, a major extracellular matrix protein of hyaline cartilage, was observed in multipotent stem cells of rat bone marrow exposed to low-power laser radiation with a wavelength of 0.63 μm and power of 1.7 mW. The result suggests that this procedure may be employed in treatment of diseases associated with damage to the surface of articular cartilage.



中文翻译:

低功率激光辐射刺激col2a1基因表达以诱导软骨形成。

摘要

在暴露于波长为0.63μm的低功率激光的大鼠骨髓多能干细胞中,观察到负责合成II型胶原(透明软骨的主要细胞外基质蛋白)的col 2 a 1基因的表达升高。功率为1.7 mW。结果表明该方法可用于治疗与关节软骨表面损伤相关的疾病。

更新日期:2020-09-14
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