Abstract

The method of scanning electron microscopy in complex with energy dispersive spectrometric analysis is applied for the first time for studying the composition of materials used or medical purposes. Cartilage implants have been formed based on polyacrylamide hydrogels reinforced by bacterial and plant celluloses, and the dynamics of variation of compositions of implant and the boundary osteal regions of a joint, indicating the dependence of osteointegration on the cellulose origin, has been demonstrated. The systems of protein delivery based on porous vaterites CaCO₃ have been investigated, and one variant of delivery systems is represented by composite systems in which the CaCO₃ matrices of the core are coated with a shell consisting of several pairs of polyelectrolyte layers. The possibility of determining the structures of polyelectrolyte shells depending on the method of their formation has been demonstrated, and the position of the encapsulated protein in CaCO₃ cores has been determined.

中文翻译：

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使用能量色散分析的扫描电子显微镜监测植入物的结构和药物输送系统

摘要

扫描电子显微镜与能量色散光谱分析相结合的方法首次用于研究所用材料或医学用途的成分。已经基于细菌和植物纤维素增强的聚丙烯酰胺水凝胶形成了软骨植入物，并且已经证明了植入物组成和关节边界骨区域的变化动态，表明骨整合对纤维素来源的依赖性。已经研究了基于多孔钙钛矿CaCO ₃的蛋白质递送系统，并且递送系统的一种变体以复合系统为代表，其中CaCO ₃核的基体上涂有由几对聚电解质层组成的壳。已经证明了根据其形成方法确定聚电解质壳的结构的可能性，并且已经确定了包封的蛋白质在CaCO ₃核中的位置。