Abstract

The results of a numerical study of heating and destruction of a biological tissue under the action of a series of focused ultrasound pulses generated by a multielement array (tumor treatment programs) are presented. Irradiation programs are considered that differ in the locations of focal points within a tissue (the Archimedean and “square” spirals), the number of pulses in the series, and the time delay between pulses. A significant influence of the parameters of the pulse series and perfusion process on the size of the thermal lesion area in a tissue was established in a considered range of moderate intensities of radiation. It was shown that the heat propagation process in the tissue turns with time to a quasi-spherical pattern and is weakly dependent on the irradiation program type. This characteristic of the process is discussed in terms of its possible use to optimize protocols of medical procedures utilizing focused ultrasound.

中文翻译：

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高强度聚焦超声：生物组织的加热和破坏

摘要

呈现了在由多元素阵列产生的一系列聚焦超声脉冲的作用下，对生物组织进行加热和破坏的数值研究的结果（肿瘤治疗程序）。认为辐照程序在组织内焦点的位置（阿基米德螺旋形和“方形”螺旋形），系列中的脉冲数以及脉冲之间的时间延迟方面有所不同。在适当的辐射强度范围内，确定了脉冲序列和灌注过程的参数对组织中热损伤区域大小的重大影响。结果表明，组织中的热传播过程随时间转变为准球形，并且几乎不依赖于照射程序类型。