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Tumor Microenvironment Cascade-Responsive Nanodrug with Self-Targeting Activation and ROS Regeneration for Synergistic Oxidation-Chemotherapy
Nano-Micro Letters ( IF 31.6 ) Pub Date : 2020-09-14 , DOI: 10.1007/s40820-020-00492-4 Yang Li 1, 2, 3 , Jinyan Lin 2 , Peiyuan Wang 1, 2, 3 , Qiang Luo 1, 2, 3 , Fukai Zhu 4 , Yun Zhang 1, 3 , Zhenqing Hou 4 , Xiaolong Liu 1, 2, 3 , Jingfeng Liu 1, 2, 3
中文翻译：
肿瘤微环境级联响应纳米药物具有自我靶向激活和ROS再生的协同氧化化疗作用
更新日期：2020-09-14
Nano-Micro Letters ( IF 31.6 ) Pub Date : 2020-09-14 , DOI: 10.1007/s40820-020-00492-4 Yang Li 1, 2, 3 , Jinyan Lin 2 , Peiyuan Wang 1, 2, 3 , Qiang Luo 1, 2, 3 , Fukai Zhu 4 , Yun Zhang 1, 3 , Zhenqing Hou 4 , Xiaolong Liu 1, 2, 3 , Jingfeng Liu 1, 2, 3
Affiliation
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A pH/ROS cascade-responsive carrier-free nanodrug with self-targeting activation and ROS regeneration abilities.
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On-demand release of VES in response to intracellular ROS to accelerate drug release via positive-feedback loop.
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Highly synergistic therapeutic efficiency via orchestrated cooperation of oxidation-chemotherapy.
中文翻译：
肿瘤微环境级联响应纳米药物具有自我靶向激活和ROS再生的协同氧化化疗作用
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一种 pH/ROS 级联响应的无载体纳米药物，具有自靶向激活和 ROS 再生能力。 -
响应细胞内 ROS 按需释放 VES，通过正反馈回路加速药物释放。 -
通过氧化化疗的精心配合，实现高度协同治疗效率。
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