Purpose

Inflammation characterized by edema, redness, and pain predominantly symptomatizes in diseases like allergies, asthma, and arthritis. Anti-inflammatory drugs like NSAIDs have been used to treat inflammation but reportedly cause severe gastrointestinal problems; therefore, new and safer drugs are sought-after for better resolution of diseases. The metal-based drugs have been proved as promising alternatives for some of the currently used drugs. The aim of this study was to evaluate antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities of new Schiff base derived metal complexes.

Methods

The antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities were performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), agar well diffusion, paw edema, and egg albumin denaturation methods respectively.

Results

Mn (II) and Co (II) complexes showed 0.65 and 1.91 IC₅₀ values and other complexes showed compelling ABTS antioxidant activity. Cu (II) and Zn (II) complexes exhibited significant antimicrobial activity against all six bacterial strains as compared with the parent Schiff base ligand.

Conclusion

The in vitro anti-inflammatory activity revealed that all the complexes inhibited inflammation in dose-dependent manner, while in vivo results indicated Ni (II) complex as potential anti-inflammatory agent. Hence our drugs were found to be potent antioxidant, antibacterial, as well as anti-inflammatory agents and might be used to suppress disease severity by inhibiting the inflammation.

中文翻译：

---

磺胺嘧啶合成的席夫碱金属配合物的生物学评价

目的

以水肿，发红和疼痛为特征的炎症主要表现为过敏，哮喘和关节炎等疾病。NSAIDs等抗炎药已用于治疗炎症，但据报道会引起严重的胃肠道问题。因此，为了更好地解决疾病，人们寻求新的和更安全的药物。金属基药物已被证明是当前一些药物的有前途的替代品。这项研究的目的是评估新型席夫碱衍生金属配合物的抗氧化，抗菌以及体内和体外的抗炎活性。

方法

抗氧化剂，抗菌剂以及体内和体外的抗炎活性是通过2,2-二苯基-1-吡啶并肼基（DPPH）和2,2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）（ ABTS），琼脂充分扩散，爪水肿和卵清蛋白变性方法。

结果

Mn（II）和Co（II）配合物显示出0.65和1.91的IC ₅₀值，其他配合物显示出引人注目的ABTS抗氧化活性。与母体席夫碱配体相比，铜（II）和锌（II）配合物表现出对所有六个细菌菌株的显着抗菌活性。

结论

体外抗炎活性表明，所有复合物均以剂量依赖性方式抑制炎症，而体内结果表明，Ni（II）复合物是潜在的抗炎剂。因此，我们的药物被发现是有效的抗氧化剂，抗菌药和消炎药，可通过抑制炎症来抑制疾病的严重程度。