Soft and stretchable biosensors have recently gained considerable attention owing to their unique capability of seamless integration with the intrinsically soft and curvilinear biological tissues for wearable/implantable health monitoring remotely. In this review, we aim to focus on surveying the recent achievements in monitoring key biological health vital markers including glucose, lactate, and cationic ions by electrochemical means. First, we discuss the soft and stretchable electrochemical electrodes (namely working, counter, and reference electrodes) from the perspectives of materials and design strategies. Then, we cover viable detection methods and modalities used in soft and stretchable biosensing systems. This is followed by description of the exciting applications of soft electrochemical biosensing systems in non-intrusive personal healthcare monitoring and in real-time monitoring of cells and tissues. This review concludes by the discussion of the challenges, opportunities, and future perspectives of soft and stretchable electrochemical biosensors.

柔软和可拉伸的生物传感器由于其与固有的柔软和曲线形生物组织无缝集成以实现远程可穿戴/可植入健康监测的独特能力，近来受到了广泛的关注。在这篇综述中，我们的重点是调查通过电化学方法监测关键生物健康重要标志物（包括葡萄糖，乳酸和阳离子）的最新成就。首先，我们从材料和设计策略的角度讨论柔软可拉伸的电化学电极（即工作电极，对电极和参比电极）。然后，我们介绍了在柔软和可拉伸的生物传感系统中使用的可行检测方法和方式。接下来是对软电化学生物传感系统在非侵入式个人医疗保健监测以及对细胞和组织的实时监测中令人兴奋的应用的描述。这篇综述以对柔软和可拉伸的电化学生物传感器的挑战，机遇和未来观点的讨论作为结束。