Early detection and easy continuous monitoring of emerging or re-emerging infectious, contagious or other diseases are of particular interest for controlling healthcare advances and developing effective medical treatments to reduce the high global cost burden of diseases in the backdrop of lack of awareness regarding advancing diseases. Under an ever-increasing demand for biosensor design reliability for early stage recognition of infectious agents or contagious diseases and potential proteins, nanoscale manufacturing designs had developed effective nanodynamic sensing assays and compact wearable devices. Dynamic developments of biosensor technology are also vital to detect and monitor advanced diseases, such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), diabetes, cancers, liver diseases, cardiovascular diseases (CVDs), tuberculosis, and central nervous system (CNS) disorders. In particular, nanoscale biosensor designs have indispensable contribution to improvement of health concerns by early detection of disease, monitoring ecological and therapeutic agents, and maintaining high safety level in food and cosmetics. This review reports an overview of biosensor designs and their feasibility for early investigation, detection, and quantitative determination of many advanced diseases. Biosensor strategies are highlighted to demonstrate the influence of nanocompact and lightweight designs on accurate analyses and inexpensive sensing assays. To date, the effective and foremost developments in various nanodynamic designs associated with simple analytical facilities and procedures remain challenging. Given the wide evolution of biosensor market requirements and the growing demand in the creation of early stage and real-time monitoring assays, precise output signals, and easy-to-wear and self-regulating analyses of diseases, innovations in biosensor designs based on novel fabrication of nanostructured platforms with active surface functionalities would produce ​remarkable biosensor devices. This review offers evidence for researchers and inventors to focus on biosensor challenge and improve fabrication of nanobiosensors to revolutionize consumer and healthcare markets.

在控制疾病进展的意识不足的背景下，早期发现和容易持续监测新出现或重新出现的传染病，传染病或其他疾病对于控制医疗保健进展和开发有效的医疗方法以减轻疾病的高全球成本负担特别重要。 。在对生物传感器设计可靠性的不断增长的需求以早期识别感染因子或传染病和潜在的蛋白质时，纳米级制造设计已经开发出有效的纳米动力学传感测定法和紧凑型可穿戴设备。生物传感器技术的动态发展对于检测和监测晚期疾病也至关重要，例如人类免疫缺陷病毒（HIV），乙型肝炎病毒（HBV），丙型肝炎病毒（HCV），糖尿病，癌症，肝病，心血管疾病（CVD），肺结核和中枢神经系统（CNS）疾病。特别是，纳米级生物传感器设计通过早期发现疾病，监测生态和治疗剂以及维持食品和化妆品的高安全性水平，对改善健康问题具有不可或缺的贡献。这篇综述报告了生物传感器设计的概述及其在许多晚期疾病的早期研究，检测和定量确定中的可行性。重点介绍了生物传感器策略，以证明纳米紧凑和轻巧设计对准确分析和廉价的传感测定的影响。迄今为止，与简单的分析设施和程序相关的各种纳米动力学设计的有效和最重要的发展仍然具有挑战性。鉴于生物传感器市场需求的广泛发展以及在建立早期和实时监测分析，精确的输出信号以及易于佩戴和自我调节的疾病分析方面不断增长的需求，基于新型生物传感器设计的创新具有活性表面功能的纳米结构平台的制造将产生显着的生物传感器设备。这篇综述为研究人员和发明者专注于生物传感器挑战并改善纳米生物传感器的制造，以彻底改变消费者和医疗保健市场提供了证据。基于具有主动表面功能的纳米结构平台的新颖制造，生物传感器设计中的创新将产生卓越的生物传感器设备。这篇综述为研究人员和发明者专注于生物传感器挑战并改进纳米生物传感器的制造，以彻底改变消费者和医疗保健市场提供了证据。基于具有主动表面功能的纳米结构平台的新颖制造，生物传感器设计中的创新将产生卓越的生物传感器设备。这篇综述为研究人员和发明者专注于生物传感器挑战并改进纳米生物传感器的制造，以彻底改变消费者和医疗保健市场提供了证据。