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Self-assembly in elastin-like recombinamers: a mechanism to mimic natural complexity
Materials Today Bio ( IF 8.7 ) Pub Date : 2019-05-20 , DOI: 10.1016/j.mtbio.2019.100007
L. Quintanilla-Sierra , C. García-Arévalo , J.C. Rodriguez-Cabello

The topic of self-assembled structures based on elastin-like recombinamers (ELRs, i.e., elastin-like polymers recombinantly bio-produced) has released a noticeable amount of references in the last few years. Most of them are intended for biomedical applications. In this review, a complete revision of the bibliography is carried out. Initially, the self-assembly (SA) concept is considered from a general point of view, and then ELRs are described and characterized based on their intrinsic disorder. A classification of the different self-assembled ELR-based structures is proposed based on their morphologies, paying special attention to their tentative modeling. The impact of the mechanism of SA on these biomaterials is analyzed. Finally, the implications of ELR SA in biological systems are considered.



中文翻译:

弹性蛋白样重组子的自组装:模仿自然复杂性的机制

在过去的几年中,基于弹性蛋白样重组蛋白(ELR,即重组生物生产的弹性蛋白样聚合物)的自组装结构的话题已经发布了引人注目的参考文献。它们中的大多数旨在用于生物医学应用。在这次审查中,对书目进行了完整的修订。最初,从一般的角度考虑自组装(SA)的概念,然后根据ELR的固有紊乱来对其进行描述和表征。根据它们的形态,提出了不同的基于自组装ELR的结构的分类,并特别注意它们的暂定建模。分析了SA机理对这些生物材料的影响。最后,考虑了ELR SA在生物系统中的含义。

更新日期:2019-05-20
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