This article describes the biological activities of heartwood extracts from Yakushima native cedar (Cryptomeria japonica) and identifies their main active compounds. Black heartwood and red heartwood were each divided into two parts from the center (the pith) to outer heartwood (the cambium). The methanol extracts of those parts were screened for antioxidant and anti-lipase activities. The extract from the pith of the red heartwood showed the highest ORAC activity among the samples. Regarding anti-lipase activity, all the extracts showed relatively high activity (the IC50 value were 9.71–37.24 μg mL−1). In addition, four compounds were isolated and identified from the pith of red heartwood by NMR and MS analyses. Agatharesinol (3) and sequirin C (4) were thought to be the main active compounds responsible for the antioxidant and anti-lipase activities.

中文翻译：

---

从屋久岛天然雪松 (Cryptomeria japonica) 心材中分离出的抗氧化和抗脂肪酶化合物

本文描述了屋久岛天然雪松 (Cryptomeria japonica) 心材提取物的生物活性，并确定了它们的主要活性化合物。黑色心材和红色心材分别从中心（髓）到外心材（形成层）分为两部分。筛选这些部分的甲醇提取物的抗氧化和抗脂肪酶活性。红心材髓中的提取物在样品中表现出最高的 ORAC 活性。关于抗脂肪酶活性，所有提取物均显示出较高的活性（IC50 值为 9.71–37.24 μg mL-1）。此外，通过核磁共振和质谱分析，从红心材的髓中分离并鉴定了四种化合物。