Abstract The demand of biomaterials in cardiovascular application was increasing day by day and its utilization is restricted by its mechanical and biocompatible properties. This paper aims to design a novel polyurethane nanocomposite added with juniper and titanium dioxide (TiO2) through electrospinning process. Wettability analysis of the composite showed its improved hydrophobic nature and its fibers were of small in size compared to pure polyurethane. Tensile strength and thermal stability of the composite increased compared to the pure polymeric fibers. Atomic force microscopy denoted the increase in surface roughness of PU with the incorporation of juniper and titanium dioxide. Anti-thrombogenic properties of the developed composites were displayed through the delayed coagulation times. Above all, human dermal fibroblast cells were actively growing without toxic issues making the fabricated material as a widely undisputed choice in cardiac tissue applications.

中文翻译：

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植入杜松油和二氧化钛的纳米纤维聚氨酯贴片具有丰富的理化特性和血液相容性，用于心脏组织工程

摘要 生物材料在心血管应用中的需求日益增加，其应用受到其力学和生物相容性的限制。本文旨在通过静电纺丝工艺设计一种添加杜松和二氧化钛 (TiO2) 的新型聚氨酯纳米复合材料。复合材料的润湿性分析表明，与纯聚氨酯相比，其改进的疏水性和纤维尺寸较小。与纯聚合物纤维相比，复合材料的拉伸强度和热稳定性有所提高。原子力显微镜表明加入杜松和二氧化钛后 PU 的表面粗糙度增加。所开发的复合材料的抗血栓形成特性通过延迟的凝固时间显示出来。首先，