Abstract In this study, one of the higher Poly α-olefins, poly1-hexene (PHex), was rationalized for possible application in in-vitro drug delivery system. In this aspect, PHex was synthesized using a conventional TiCl4/MgCl2/TEAL Ziegler-Natta catalyst. The synthesized polymer was characterized by NMR, GPC, and cellular toxicity methods. Then, the effect of triethylcitrate and glycerin plasticizers on the topography, water vapor permeation and water sorption properties of the prepared fabricates was investigated. Finally, in-vitro drug release characteristic of the gentamicin loaded PHex and PHex/TEC samples was evaluated during eight days. Obtained results highlighted the potential of PHex elastomer in developing medical devices with enhanced drug release characteristics.

中文翻译：

---

评估负载 GS 的聚 1-己烯作为一种新的弹性体药物释放系统

摘要 在这项研究中，一种高级聚 α-烯烃，聚 1-己烯 (PHex)，被合理化以用于体外药物递送系统的可能应用。在这方面，PHex 是使用传统的 TiCl4/MgCl2/TEAL Ziegler-Natta 催化剂合成的。合成的聚合物通过核磁共振、GPC 和细胞毒性方法进行表征。然后，研究了柠檬酸三乙酯和甘油增塑剂对制备的制品的形貌、水蒸气渗透和吸水性能的影响。最后，在八天内评估了负载庆大霉素的 PHex 和 PHex/TEC 样品的体外药物释放特性。获得的结果突出了 PHex 弹性体在开发具有增强药物释放特性的医疗器械方面的潜力。